Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease

Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson's disease. It was recently observed in a rodent model of Alzheimer's disease that the interaction between the a7 subtype of nicotinic acetylcholine receptor (a7-nAChR) and...

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Bibliographic Details
Main Authors: Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalon
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
6-hydroxydopamine; astrocytes; microglial activation; neurodegeneration; neuroinflammation; nicotinic a7 receptor; parkinson's disease; pha 543613; pre-084; sigma-1 receptor
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=6;spage=1099;epage=1104;aulast=

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