Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSummary

Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSummary

Background & Aims: We used patient-derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease (CD) with varying phenotypes to screen for disease profiles and potential druggable targets. Methods: RNA sequencing was p...

Full description

Bibliographic Details
Main Authors: Barbara Joanna Niklinska-Schirtz, Suresh Venkateswaran, Murugadas Anbazhagan, Vasantha L. Kolachala, Jarod Prince, Anne Dodd, Raghavan Chinnadurai, Gregory Gibson, Lee A. Denson, David J. Cutler, Anil G. Jegga, Jason D. Matthews, Subra Kugathasan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Inflammatory Bowel Disease
Human Intestinal Organoids
Children
Epigenetics
Intestinal Epithelium
Secretome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21001338

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X21001338

Similar Items