Medicinal Plants and Natural Products Used in Cataract Management
Cataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms in...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00466/full |
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| author | Devesh Tewari Ovidiu Samoilă Diana Gocan Andrei Mocan Cadmiel Moldovan Hari Prasad Devkota Atanas G. Atanasov Atanas G. Atanasov Gokhan Zengin Javier Echeverría Dan Vodnar Bianca Szabo Gianina Crişan |
| author_facet | Devesh Tewari Ovidiu Samoilă Diana Gocan Andrei Mocan Cadmiel Moldovan Hari Prasad Devkota Atanas G. Atanasov Atanas G. Atanasov Gokhan Zengin Javier Echeverría Dan Vodnar Bianca Szabo Gianina Crişan |
| author_sort | Devesh Tewari |
| collection | DOAJ |
| description | Cataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the development of age-related cataract. Surgery through phacoemulsification and intraocular lens implantation is the most effective method for cataract treatment, however, there are chances of serious complications and irreversible loss of vision associated with the surgery. Natural compounds consisting of antioxidant or anti-inflammatory secondary metabolites can serve as potential leads for anticataract agents. In this review, we tried to document medicinal plants and plant-based natural products used for cataract treatment worldwide, which are gathered from available ethnopharmacological/ethnobotanical data. We have extensively explored a number of recognized databases like Scifinder, PubMed, Science Direct, Google Scholar, and Scopus by using keywords and phrases such as “cataract”, “blindness”, “traditional medicine”, “ethnopharmacology”, “ethnobotany”, “herbs”, “medicinal plants”, or other relevant terms, and summarized the plants/phytoconstituents that are evaluated in different models of cataract and also tabulated 44 plants that are traditionally used in cataract in various folklore medical practices. Moreover, we also categorized the plants according to scientific studies carried out in different cataract models with their mechanisms of action. |
| first_indexed | 2024-04-13T03:21:33Z |
| format | Article |
| id | doaj.art-138ef55f5dcc494384e45f9b9bd57d35 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T03:21:33Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-138ef55f5dcc494384e45f9b9bd57d352022-12-22T03:04:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-06-011010.3389/fphar.2019.00466419743Medicinal Plants and Natural Products Used in Cataract ManagementDevesh Tewari0Ovidiu Samoilă1Diana Gocan2Andrei Mocan3Cadmiel Moldovan4Hari Prasad Devkota5Atanas G. Atanasov6Atanas G. Atanasov7Gokhan Zengin8Javier Echeverría9Dan Vodnar10Bianca Szabo11Gianina Crişan12Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, IndiaDepartment of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, JapanInstitute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, PolandDepartment of Pharmacognosy, University of Vienna, Vienna, AustriaDepartment of Biology, Faculty of Science, Selcuk University, Konya, TurkeyDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileDepartment of Food Science, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Cluj-Napoca, Romania0Department of Anatomy, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the development of age-related cataract. Surgery through phacoemulsification and intraocular lens implantation is the most effective method for cataract treatment, however, there are chances of serious complications and irreversible loss of vision associated with the surgery. Natural compounds consisting of antioxidant or anti-inflammatory secondary metabolites can serve as potential leads for anticataract agents. In this review, we tried to document medicinal plants and plant-based natural products used for cataract treatment worldwide, which are gathered from available ethnopharmacological/ethnobotanical data. We have extensively explored a number of recognized databases like Scifinder, PubMed, Science Direct, Google Scholar, and Scopus by using keywords and phrases such as “cataract”, “blindness”, “traditional medicine”, “ethnopharmacology”, “ethnobotany”, “herbs”, “medicinal plants”, or other relevant terms, and summarized the plants/phytoconstituents that are evaluated in different models of cataract and also tabulated 44 plants that are traditionally used in cataract in various folklore medical practices. Moreover, we also categorized the plants according to scientific studies carried out in different cataract models with their mechanisms of action.https://www.frontiersin.org/article/10.3389/fphar.2019.00466/fullmedicinal plantsnatural productscataractantioxidantaldose reductaselens opacity |
| spellingShingle | Devesh Tewari Ovidiu Samoilă Diana Gocan Andrei Mocan Cadmiel Moldovan Hari Prasad Devkota Atanas G. Atanasov Atanas G. Atanasov Gokhan Zengin Javier Echeverría Dan Vodnar Bianca Szabo Gianina Crişan Medicinal Plants and Natural Products Used in Cataract Management Frontiers in Pharmacology medicinal plants natural products cataract antioxidant aldose reductase lens opacity |
| title | Medicinal Plants and Natural Products Used in Cataract Management |
| title_full | Medicinal Plants and Natural Products Used in Cataract Management |
| title_fullStr | Medicinal Plants and Natural Products Used in Cataract Management |
| title_full_unstemmed | Medicinal Plants and Natural Products Used in Cataract Management |
| title_short | Medicinal Plants and Natural Products Used in Cataract Management |
| title_sort | medicinal plants and natural products used in cataract management |
| topic | medicinal plants natural products cataract antioxidant aldose reductase lens opacity |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00466/full |
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