Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery
<p class="p p-first-last" id="__p2">Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Copernicus Publications
2017-01-01
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| Series: | Journal of Bone and Joint Infection |
| Online Access: | https://jbji.copernicus.org/articles/2/23/2017/jbji-2-23-2017.pdf |
| _version_ | 1818665540879646720 |
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| author | A. N. Fleischman M. S. Austin |
| author_facet | A. N. Fleischman M. S. Austin |
| author_sort | A. N. Fleischman |
| collection | DOAJ |
| description | <p class="p p-first-last" id="__p2">Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery.</p> |
| first_indexed | 2024-12-17T05:50:16Z |
| format | Article |
| id | doaj.art-13919b3f51ba4dd6a1f4fdbc14a8b00f |
| institution | Directory Open Access Journal |
| issn | 2206-3552 |
| language | English |
| last_indexed | 2024-12-17T05:50:16Z |
| publishDate | 2017-01-01 |
| publisher | Copernicus Publications |
| record_format | Article |
| series | Journal of Bone and Joint Infection |
| spelling | doaj.art-13919b3f51ba4dd6a1f4fdbc14a8b00f2022-12-21T22:01:11ZengCopernicus PublicationsJournal of Bone and Joint Infection2206-35522017-01-012232810.7150/jbji.16649Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic SurgeryA. N. Fleischman0M. S. Austin1Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, United States.Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, United States.<p class="p p-first-last" id="__p2">Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery.</p>https://jbji.copernicus.org/articles/2/23/2017/jbji-2-23-2017.pdf |
| spellingShingle | A. N. Fleischman M. S. Austin Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery Journal of Bone and Joint Infection |
| title | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
| title_full | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
| title_fullStr | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
| title_full_unstemmed | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
| title_short | Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery |
| title_sort | local intra wound administration of powdered antibiotics in orthopaedic surgery |
| url | https://jbji.copernicus.org/articles/2/23/2017/jbji-2-23-2017.pdf |
| work_keys_str_mv | AT anfleischman localintrawoundadministrationofpowderedantibioticsinorthopaedicsurgery AT msaustin localintrawoundadministrationofpowderedantibioticsinorthopaedicsurgery |