Ocular histopathology in Eastern equine encephalitis: A case report
Purpose: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). Observations: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent with viral meningoencephalitis. ELISA sugges...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993616301487 |
| _version_ | 1819026023222607872 |
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| author | Eleonora M. Lad Sally S. Ong Alan D. Proia |
| author_facet | Eleonora M. Lad Sally S. Ong Alan D. Proia |
| author_sort | Eleonora M. Lad |
| collection | DOAJ |
| description | Purpose: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE).
Observations: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent with viral meningoencephalitis. ELISA suggested recent infection with EEE virus. Microscopic analysis of the brain demonstrated perivascular lymphohistiocytic cuffing which was consistent with viral type encephalitis. Similarly, both eyes manifested a lymphohistiocytic infiltrate in the retina and optic nerve and a reduced number of ganglion cells.
Conclusions and importance: To our knowledge, this is the first report of ophthalmological and ocular pathology observations in an EEE patient. Interestingly, the inflammatory findings in the retina are reminiscent of the central nervous system effects of EEE virus. These findings are relevant given the recent epidemic of microcephaly and ophthalmic complications secondary to another arboviral virus, the Zika virus. |
| first_indexed | 2024-12-21T05:19:59Z |
| format | Article |
| id | doaj.art-1394131a7b904b558e5822d5e4d4d693 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-21T05:19:59Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-1394131a7b904b558e5822d5e4d4d6932022-12-21T19:14:50ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362017-04-015C9910210.1016/j.ajoc.2016.12.021Ocular histopathology in Eastern equine encephalitis: A case reportEleonora M. Lad0Sally S. Ong1Alan D. Proia2Department of Ophthalmology, Duke University Medical Center, DUMC 3802, Durham, NC 27710, United StatesDepartment of Ophthalmology, Duke University Medical Center, DUMC 3802, Durham, NC 27710, United StatesDepartment of Ophthalmology, Duke University Medical Center, DUMC 3802, Durham, NC 27710, United StatesPurpose: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). Observations: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent with viral meningoencephalitis. ELISA suggested recent infection with EEE virus. Microscopic analysis of the brain demonstrated perivascular lymphohistiocytic cuffing which was consistent with viral type encephalitis. Similarly, both eyes manifested a lymphohistiocytic infiltrate in the retina and optic nerve and a reduced number of ganglion cells. Conclusions and importance: To our knowledge, this is the first report of ophthalmological and ocular pathology observations in an EEE patient. Interestingly, the inflammatory findings in the retina are reminiscent of the central nervous system effects of EEE virus. These findings are relevant given the recent epidemic of microcephaly and ophthalmic complications secondary to another arboviral virus, the Zika virus.http://www.sciencedirect.com/science/article/pii/S2451993616301487Eastern equine encephalitis, EEEPathologyArbovirusEye |
| spellingShingle | Eleonora M. Lad Sally S. Ong Alan D. Proia Ocular histopathology in Eastern equine encephalitis: A case report American Journal of Ophthalmology Case Reports Eastern equine encephalitis, EEE Pathology Arbovirus Eye |
| title | Ocular histopathology in Eastern equine encephalitis: A case report |
| title_full | Ocular histopathology in Eastern equine encephalitis: A case report |
| title_fullStr | Ocular histopathology in Eastern equine encephalitis: A case report |
| title_full_unstemmed | Ocular histopathology in Eastern equine encephalitis: A case report |
| title_short | Ocular histopathology in Eastern equine encephalitis: A case report |
| title_sort | ocular histopathology in eastern equine encephalitis a case report |
| topic | Eastern equine encephalitis, EEE Pathology Arbovirus Eye |
| url | http://www.sciencedirect.com/science/article/pii/S2451993616301487 |
| work_keys_str_mv | AT eleonoramlad ocularhistopathologyineasternequineencephalitisacasereport AT sallysong ocularhistopathologyineasternequineencephalitisacasereport AT alandproia ocularhistopathologyineasternequineencephalitisacasereport |