Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience
Abstract Background This study was designed to investigate clinical efficiency and application indications of hepatic lobe hyperplasia techniques for advanced hepatic alveolar echinococcosis (AE) patients. Methods A retrospective case series covering 19 advanced hepatic AE patients admitted to the F...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-022-01864-w |
| _version_ | 1811177851717681152 |
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| author | Qiang Guo Maolin Wang Kai Zhong Jialong Li Tiemin Jiang Bo Ran Paizula Shalayiadang Ruiqing Zhang Talaiti Tuergan Tuerganaili Aji Yingmei Shao |
| author_facet | Qiang Guo Maolin Wang Kai Zhong Jialong Li Tiemin Jiang Bo Ran Paizula Shalayiadang Ruiqing Zhang Talaiti Tuergan Tuerganaili Aji Yingmei Shao |
| author_sort | Qiang Guo |
| collection | DOAJ |
| description | Abstract Background This study was designed to investigate clinical efficiency and application indications of hepatic lobe hyperplasia techniques for advanced hepatic alveolar echinococcosis (AE) patients. Methods A retrospective case series covering 19 advanced hepatic AE patients admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2014 to December 2021 and undergoing hepatic lobe hyperplasia techniques due to insufficient remnant liver volume were analyzed. Changes of liver function, lesions volume, remnant liver volume, total liver volume before and after operation have been observed. Results Among the patients, 15 underwent portal vein embolization (PVE). There was no statistical difference in total liver volume and lesions volume before and after PVE (P > 0.05). However, the remnant liver volume was significantly increased after PVE (P < 0.05). The median monthly increase rate in future liver remnant volume (FLRV) after PVE stood at 4.49% (IQR 3.55–7.06). Among the four patients undergoing two-stage hepatectomy (TSH), FLRV was larger than that before the first stage surgery, and the median monthly increase rate in FLRV after it stood at 3.34% (IQR 2.17–4.61). Despite no statistical difference in total bilirubin (TBil), albumin (Alb), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) in all patients with PVE, four patients who underwent TSH showed a decrease in ALT, AST and GGT. During the waiting process before the second stage operation, no serious complications occurred in all patients. Conclusions For patients suffering from advanced hepatic AE with insufficient FLRV, PVE and TSH are safe and feasible in promoting hepatic lobe hyperplasia. |
| first_indexed | 2024-04-11T06:09:20Z |
| format | Article |
| id | doaj.art-139464317cd143a7a33223c4ec9ace77 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-04-11T06:09:20Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-139464317cd143a7a33223c4ec9ace772022-12-22T04:41:22ZengBMCBMC Surgery1471-24822022-12-0122111010.1186/s12893-022-01864-wApplication of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experienceQiang Guo0Maolin Wang1Kai Zhong2Jialong Li3Tiemin Jiang4Bo Ran5Paizula Shalayiadang6Ruiqing Zhang7Talaiti Tuergan8Tuerganaili Aji9Yingmei Shao10Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical UniversityAbstract Background This study was designed to investigate clinical efficiency and application indications of hepatic lobe hyperplasia techniques for advanced hepatic alveolar echinococcosis (AE) patients. Methods A retrospective case series covering 19 advanced hepatic AE patients admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2014 to December 2021 and undergoing hepatic lobe hyperplasia techniques due to insufficient remnant liver volume were analyzed. Changes of liver function, lesions volume, remnant liver volume, total liver volume before and after operation have been observed. Results Among the patients, 15 underwent portal vein embolization (PVE). There was no statistical difference in total liver volume and lesions volume before and after PVE (P > 0.05). However, the remnant liver volume was significantly increased after PVE (P < 0.05). The median monthly increase rate in future liver remnant volume (FLRV) after PVE stood at 4.49% (IQR 3.55–7.06). Among the four patients undergoing two-stage hepatectomy (TSH), FLRV was larger than that before the first stage surgery, and the median monthly increase rate in FLRV after it stood at 3.34% (IQR 2.17–4.61). Despite no statistical difference in total bilirubin (TBil), albumin (Alb), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) in all patients with PVE, four patients who underwent TSH showed a decrease in ALT, AST and GGT. During the waiting process before the second stage operation, no serious complications occurred in all patients. Conclusions For patients suffering from advanced hepatic AE with insufficient FLRV, PVE and TSH are safe and feasible in promoting hepatic lobe hyperplasia.https://doi.org/10.1186/s12893-022-01864-wHepatic alveolar echinococcosisSelective portal vein embolizationTwo-stage hepatectomyFuture liver remnant volume |
| spellingShingle | Qiang Guo Maolin Wang Kai Zhong Jialong Li Tiemin Jiang Bo Ran Paizula Shalayiadang Ruiqing Zhang Talaiti Tuergan Tuerganaili Aji Yingmei Shao Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience BMC Surgery Hepatic alveolar echinococcosis Selective portal vein embolization Two-stage hepatectomy Future liver remnant volume |
| title | Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience |
| title_full | Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience |
| title_fullStr | Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience |
| title_full_unstemmed | Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience |
| title_short | Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience |
| title_sort | application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis a single centre experience |
| topic | Hepatic alveolar echinococcosis Selective portal vein embolization Two-stage hepatectomy Future liver remnant volume |
| url | https://doi.org/10.1186/s12893-022-01864-w |
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