Transcription Factor β-Catenin Plays a Key Role in Fluid Flow Shear Stress-Mediated Glomerular Injury in Solitary Kidney

Transcription Factor β-Catenin Plays a Key Role in Fluid Flow Shear Stress-Mediated Glomerular Injury in Solitary Kidney

Increased fluid flow shear stress (FFSS) in solitary kidney alters podocyte function <i>in vivo</i>. FFSS-treated cultured podocytes show upregulated AKT-GSK3β-β-catenin signaling. The present study was undertaken to confirm (i) the activation of β-catenin signaling in podocytes in vivo...

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Bibliographic Details
Main Authors: Tarak Srivastava, Daniel P. Heruth, R. Scott Duncan, Mohammad H. Rezaiekhaligh, Robert E. Garola, Lakshmi Priya, Jianping Zhou, Varun C. Boinpelly, Jan Novak, Mohammed Farhan Ali, Trupti Joshi, Uri S. Alon, Yuexu Jiang, Ellen T. McCarthy, Virginia J. Savin, Ram Sharma, Mark L. Johnson, Mukut Sharma
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
podocytes
fluid flow shear stress
glomerular hemodynamics
hyperfiltration
glomerular filtration barrier
Online Access:https://www.mdpi.com/2073-4409/10/5/1253

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