| Summary: | Transcranial direct current stimulation (tDCS) can improve motor learning. However, the effects of tDCS on the performance of a motor learning task, the choice reaction time task, remain elusive. Here, we examined the effects of tDCS on the learning and memory of a 4-choice visual-motor reaction time task (4-ChRT). Participants were randomly assigned to three tDCS groups: before (tDCSbefore), during (tDCSduring), or after (tDCSafter) motor practice, and two control groups, with (CONmp) and without (CON) motor practice. We studied the reaction time and error rate of the 4-ChRT task before (Pre), during, and 24 h (Post) after the motor practice and tDCS. We found that motor practice can improve motor learning and tDCS during motor practice can most effectively reduce reaction time and error rate. These results will shed light on future study of using non-invasive brain stimulation to improve motor function in patients with motor disorders.
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