Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis

Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis

In individuals with cystic fibrosis (CF), lung hyper-inflammation starts early in life and is perpetuated by mucus obstruction and persistent bacterial infections. The continuous tissue damage and scarring caused by non-resolving inflammation leads to bronchiectasis and, ultimately, respiratory fail...

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Bibliographic Details
Main Authors: Caterina Di Pietro, Hasan H. Öz, Thomas S. Murray, Emanuela M. Bruscia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
monocyte/macrophages
heme oxygenase-1 (HO-1)
carbon monoxide (CO)
CO-releasing molecules
lung inflammation
cystic fibrosis (CF)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01059/full

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