A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret abe...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224000238 |
| _version_ | 1797263593101590528 |
|---|---|
| author | Kyle M. Jensen Vince D. Calhoun Zening Fu Kun Yang Andreia V. Faria Koko Ishizuka Akira Sawa Pablo Andrés-Camazón Brian A. Coffman Dylan Seebold Jessica A. Turner Dean F. Salisbury Armin Iraji |
| author_facet | Kyle M. Jensen Vince D. Calhoun Zening Fu Kun Yang Andreia V. Faria Koko Ishizuka Akira Sawa Pablo Andrés-Camazón Brian A. Coffman Dylan Seebold Jessica A. Turner Dean F. Salisbury Armin Iraji |
| author_sort | Kyle M. Jensen |
| collection | DOAJ |
| description | Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and other confounds. The current study uses a data-driven whole-brain approach to examine patterns of aberrant functional network connectivity (FNC) in a multi-site dataset comprising resting-state functional magnetic resonance images (rs-fMRI) from 117 individuals with FEP or EP and 130 individuals without a psychiatric disorder, as controls. Accounting for age, sex, race, head motion, and multiple imaging sites, differences in FNC were identified between psychosis and control participants in cortical (namely the inferior frontal gyrus, superior medial frontal gyrus, postcentral gyrus, supplementary motor area, posterior cingulate cortex, and superior and middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, and hippocampus), and cerebellar regions. The prominent pattern of reduced cerebellar connectivity in psychosis is especially noteworthy, as most studies focus on cortical and subcortical regions, neglecting the cerebellum. The dysconnectivity reported here may indicate disruptions in cortical-subcortical-cerebellar circuitry involved in rudimentary cognitive functions which may serve as reliable correlates of psychosis. |
| first_indexed | 2024-03-07T19:09:01Z |
| format | Article |
| id | doaj.art-1395a4a623bd4543afa39157ddbaab44 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-25T00:15:28Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-1395a4a623bd4543afa39157ddbaab442024-03-13T04:45:41ZengElsevierNeuroImage: Clinical2213-15822024-01-0141103584A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitryKyle M. Jensen0Vince D. Calhoun1Zening Fu2Kun Yang3Andreia V. Faria4Koko Ishizuka5Akira Sawa6Pablo Andrés-Camazón7Brian A. Coffman8Dylan Seebold9Jessica A. Turner10Dean F. Salisbury11Armin Iraji12Georgia State University, Atlanta, GA, USA; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USA; Corresponding author at: Department of Psychology, Georgia State University, P.O. Box 5010, Atlanta, GA 30302-5010, USA.Georgia State University, Atlanta, GA, USA; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USAGeorgia State University, Atlanta, GA, USA; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USAJohns Hopkins University School of Medicine, Baltimore, MD, USAJohns Hopkins University School of Medicine, Baltimore, MD, USAJohns Hopkins University School of Medicine, Baltimore, MD, USAJohns Hopkins University School of Medicine, Baltimore, MD, USA; Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USATri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USA; Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, SpainUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USAUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USAWexner Medical Center, The Ohio State University, Columbus, OH, USAUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USAGeorgia State University, Atlanta, GA, USA; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Atlanta, GA, USAPsychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and other confounds. The current study uses a data-driven whole-brain approach to examine patterns of aberrant functional network connectivity (FNC) in a multi-site dataset comprising resting-state functional magnetic resonance images (rs-fMRI) from 117 individuals with FEP or EP and 130 individuals without a psychiatric disorder, as controls. Accounting for age, sex, race, head motion, and multiple imaging sites, differences in FNC were identified between psychosis and control participants in cortical (namely the inferior frontal gyrus, superior medial frontal gyrus, postcentral gyrus, supplementary motor area, posterior cingulate cortex, and superior and middle temporal gyri), subcortical (the caudate, thalamus, subthalamus, and hippocampus), and cerebellar regions. The prominent pattern of reduced cerebellar connectivity in psychosis is especially noteworthy, as most studies focus on cortical and subcortical regions, neglecting the cerebellum. The dysconnectivity reported here may indicate disruptions in cortical-subcortical-cerebellar circuitry involved in rudimentary cognitive functions which may serve as reliable correlates of psychosis.http://www.sciencedirect.com/science/article/pii/S2213158224000238First-episode psychosis (FEP)Early psychosis (EP)Functional network connectivity (FNC)SchizophreniaResting-state fMRIIndependent component analysis (ICA) |
| spellingShingle | Kyle M. Jensen Vince D. Calhoun Zening Fu Kun Yang Andreia V. Faria Koko Ishizuka Akira Sawa Pablo Andrés-Camazón Brian A. Coffman Dylan Seebold Jessica A. Turner Dean F. Salisbury Armin Iraji A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry NeuroImage: Clinical First-episode psychosis (FEP) Early psychosis (EP) Functional network connectivity (FNC) Schizophrenia Resting-state fMRI Independent component analysis (ICA) |
| title | A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry |
| title_full | A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry |
| title_fullStr | A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry |
| title_full_unstemmed | A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry |
| title_short | A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry |
| title_sort | whole brain neuromark resting state fmri analysis of first episode and early psychosis evidence of aberrant cortical subcortical cerebellar functional circuitry |
| topic | First-episode psychosis (FEP) Early psychosis (EP) Functional network connectivity (FNC) Schizophrenia Resting-state fMRI Independent component analysis (ICA) |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224000238 |
| work_keys_str_mv | AT kylemjensen awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT vincedcalhoun awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT zeningfu awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT kunyang awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT andreiavfaria awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT kokoishizuka awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT akirasawa awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT pabloandrescamazon awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT brianacoffman awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT dylanseebold awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT jessicaaturner awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT deanfsalisbury awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT arminiraji awholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT kylemjensen wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT vincedcalhoun wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT zeningfu wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT kunyang wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT andreiavfaria wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT kokoishizuka wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT akirasawa wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT pabloandrescamazon wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT brianacoffman wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT dylanseebold wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT jessicaaturner wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT deanfsalisbury wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry AT arminiraji wholebrainneuromarkrestingstatefmrianalysisoffirstepisodeandearlypsychosisevidenceofaberrantcorticalsubcorticalcerebellarfunctionalcircuitry |