Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?
Summary: Candida albicans, an oral fungal opportunistic pathogen, has shown the ability to colonize implant surfaces and has been frequently isolated from biofilms associated with dental implant-related infections, possibly due to its synergistic interactions with certain oral bacteria. Moreover, ev...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222002644 |
| _version_ | 1818157499369390080 |
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| author | João G.S. Souza Raphael C. Costa Aline A. Sampaio Victória L. Abdo Bruna E. Nagay Nidia Castro Belén Retamal-Valdes Jamil A. Shibli Magda Feres Valentim A.R. Barão Martinna Bertolini |
| author_facet | João G.S. Souza Raphael C. Costa Aline A. Sampaio Victória L. Abdo Bruna E. Nagay Nidia Castro Belén Retamal-Valdes Jamil A. Shibli Magda Feres Valentim A.R. Barão Martinna Bertolini |
| author_sort | João G.S. Souza |
| collection | DOAJ |
| description | Summary: Candida albicans, an oral fungal opportunistic pathogen, has shown the ability to colonize implant surfaces and has been frequently isolated from biofilms associated with dental implant-related infections, possibly due to its synergistic interactions with certain oral bacteria. Moreover, evidence suggests that this cross-kingdom interaction on implant can encourage bacterial growth, leading to increased fungal virulence and mucosal damage. However, the role of Candida in implant-related infections has been overlooked and not widely explored or even considered by most microbiological analyses and therapeutic approaches. Thus, we summarized the scientific evidence regarding the ability of C. albicans to colonize implant surfaces, interact in implant-related polymicrobial biofilms, and its possible role in peri-implant infections as far as biologic plausibility. Next, a systematic review of preclinical and clinical studies was conducted to identify the relevance and the gap in the existing literature regarding the role of C. albicans in the pathogenesis of peri-implant infections. |
| first_indexed | 2024-12-11T15:15:10Z |
| format | Article |
| id | doaj.art-13966d9e33a14144954bbc367b9e2fa3 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-11T15:15:10Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-13966d9e33a14144954bbc367b9e2fa32022-12-22T01:00:36ZengElsevieriScience2589-00422022-04-01254103994Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?João G.S. Souza0Raphael C. Costa1Aline A. Sampaio2Victória L. Abdo3Bruna E. Nagay4Nidia Castro5Belén Retamal-Valdes6Jamil A. Shibli7Magda Feres8Valentim A.R. Barão9Martinna Bertolini10Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, Brazil; Dental Science School (Faculdade de Ciências Odontológicas - FCO), Montes Claros, Minas Gerais 39401-303, Brazil; Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil; Corresponding authorDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, BrazilDepartment of Clinic, Pathology and Dental Surgery, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 31270-901, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, BrazilDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, BrazilDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Sāo Paulo 07023-070, BrazilDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil; Corresponding authorDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pennsylvania 15260, USASummary: Candida albicans, an oral fungal opportunistic pathogen, has shown the ability to colonize implant surfaces and has been frequently isolated from biofilms associated with dental implant-related infections, possibly due to its synergistic interactions with certain oral bacteria. Moreover, evidence suggests that this cross-kingdom interaction on implant can encourage bacterial growth, leading to increased fungal virulence and mucosal damage. However, the role of Candida in implant-related infections has been overlooked and not widely explored or even considered by most microbiological analyses and therapeutic approaches. Thus, we summarized the scientific evidence regarding the ability of C. albicans to colonize implant surfaces, interact in implant-related polymicrobial biofilms, and its possible role in peri-implant infections as far as biologic plausibility. Next, a systematic review of preclinical and clinical studies was conducted to identify the relevance and the gap in the existing literature regarding the role of C. albicans in the pathogenesis of peri-implant infections.http://www.sciencedirect.com/science/article/pii/S2589004222002644Mycologymicrobiofilms |
| spellingShingle | João G.S. Souza Raphael C. Costa Aline A. Sampaio Victória L. Abdo Bruna E. Nagay Nidia Castro Belén Retamal-Valdes Jamil A. Shibli Magda Feres Valentim A.R. Barão Martinna Bertolini Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? iScience Mycology microbiofilms |
| title | Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? |
| title_full | Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? |
| title_fullStr | Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? |
| title_full_unstemmed | Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? |
| title_short | Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain? |
| title_sort | cross kingdom microbial interactions in dental implant related infections is candida albicans a new villain |
| topic | Mycology microbiofilms |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222002644 |
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