Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers
<p>Abstract</p> <p>Introduction</p> <p>Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients.</p> &l...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-11-01
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| Series: | Journal of Occupational Medicine and Toxicology |
| Online Access: | http://www.occup-med.com/content/4/1/30 |
| _version_ | 1817993667322839040 |
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| author | Raffi Francois Houdebine Marietherese Guillaumin Guyonne Gordeeff Claire Durand-Perdriel Marie-Henriette Bourrut-Lacouture Martine Muller Jean-Yves Naudin Frederique Germaud Patrick Chailleux Edmond Audrain Marie Nael Virginie Brunet-Courtois Benedicte Tripodi Dominique Boutoille David Biron Charlotte Potel Gilles Roedlich Claude Geraut Christian Schablon Anja Nienhaus Albert |
| author_facet | Raffi Francois Houdebine Marietherese Guillaumin Guyonne Gordeeff Claire Durand-Perdriel Marie-Henriette Bourrut-Lacouture Martine Muller Jean-Yves Naudin Frederique Germaud Patrick Chailleux Edmond Audrain Marie Nael Virginie Brunet-Courtois Benedicte Tripodi Dominique Boutoille David Biron Charlotte Potel Gilles Roedlich Claude Geraut Christian Schablon Anja Nienhaus Albert |
| author_sort | Raffi Francois |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients.</p> <p>Methods</p> <p>Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST ≥ 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered.</p> <p>Results</p> <p>All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST ≥ 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation.</p> <p>Conclusion</p> <p>The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST.</p> |
| first_indexed | 2024-04-14T01:42:50Z |
| format | Article |
| id | doaj.art-1399134da3dd4fa7b1033b3e984f6f08 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-14T01:42:50Z |
| publishDate | 2009-11-01 |
| publisher | BMC |
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| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-1399134da3dd4fa7b1033b3e984f6f082022-12-22T02:19:39ZengBMCJournal of Occupational Medicine and Toxicology1745-66732009-11-01413010.1186/1745-6673-4-30Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workersRaffi FrancoisHoudebine MariethereseGuillaumin GuyonneGordeeff ClaireDurand-Perdriel Marie-HenrietteBourrut-Lacouture MartineMuller Jean-YvesNaudin FrederiqueGermaud PatrickChailleux EdmondAudrain MarieNael VirginieBrunet-Courtois BenedicteTripodi DominiqueBoutoille DavidBiron CharlottePotel GillesRoedlich ClaudeGeraut ChristianSchablon AnjaNienhaus Albert<p>Abstract</p> <p>Introduction</p> <p>Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients.</p> <p>Methods</p> <p>Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST ≥ 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered.</p> <p>Results</p> <p>All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST ≥ 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation.</p> <p>Conclusion</p> <p>The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST.</p>http://www.occup-med.com/content/4/1/30 |
| spellingShingle | Raffi Francois Houdebine Marietherese Guillaumin Guyonne Gordeeff Claire Durand-Perdriel Marie-Henriette Bourrut-Lacouture Martine Muller Jean-Yves Naudin Frederique Germaud Patrick Chailleux Edmond Audrain Marie Nael Virginie Brunet-Courtois Benedicte Tripodi Dominique Boutoille David Biron Charlotte Potel Gilles Roedlich Claude Geraut Christian Schablon Anja Nienhaus Albert Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers Journal of Occupational Medicine and Toxicology |
| title | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| title_full | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| title_fullStr | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| title_full_unstemmed | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| title_short | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
| title_sort | evaluation of the tuberculin skin test and the interferon γ release assay for tb screening in french healthcare workers |
| url | http://www.occup-med.com/content/4/1/30 |
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