Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy
Abstract Background To investigate the differential contribution of the left atrial (LA) function and left ventricular (LV) fibrosis to pulmonary arterial systolic pressure (PASP) in hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and reperfused acute myocardial infarction (AMI). Met...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02952-8 |
| _version_ | 1811215880936226816 |
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| author | Minjeong Kim Hyemoon Chung In-Soo Kim Chul Hwan Park Se-Joong Rim Eui-Young Choi |
| author_facet | Minjeong Kim Hyemoon Chung In-Soo Kim Chul Hwan Park Se-Joong Rim Eui-Young Choi |
| author_sort | Minjeong Kim |
| collection | DOAJ |
| description | Abstract Background To investigate the differential contribution of the left atrial (LA) function and left ventricular (LV) fibrosis to pulmonary arterial systolic pressure (PASP) in hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and reperfused acute myocardial infarction (AMI). Methods Data of 370 patients with HCM (n = 133), DCM (n = 114) and reperfused AMI (n = 123) who underwent both echocardiography and cardiovascular magnetic resonance (CMR) were comprehensively reviewed. Phasic LA volumes, LA-global longitudinal strain (GLS), LA stiffness index, defined as E/e′/LA-GLS and extracellular volume fraction (ECV) of LV were measured using CMR. Results E/e′ was correlated with PASP in all groups; however, the predicted value was significantly attenuated after adjusting for LA volume and LA strain in HCM and DCM, but remained significant in AMI. The LA stiffness index was related to PASP in HCM (p = 0.01) and DCM (p = 0.03) independent of LA volume index and E/e′, but not in AMI. In DCM, ECV was significantly related to PASP (p < 0.001) independent of LA volume index and E/e′. When subdivided according to the linear regression between PASP and E/e′, patients in the discrepantly high PASP group had lower total emptying fraction and reservoir fraction of left atrium in HCM and DCM but not in AMI. Conclusions The LA function in HCM and DCM and LV fibrosis in DCM correlated with PASP independent of E/e′ and LA size, contrary to that in AMI. These results suggest the presence of LA dysfunction in non-ischemic cardiomyopathies and usefulness of ECV measurement in DCM for the comprehensive evaluation of LV diastolic function. |
| first_indexed | 2024-04-12T06:29:53Z |
| format | Article |
| id | doaj.art-139bbfe17ea54896a523115acffe9c18 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T06:29:53Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-139bbfe17ea54896a523115acffe9c182022-12-22T03:44:02ZengBMCBMC Cardiovascular Disorders1471-22612022-11-0122111110.1186/s12872-022-02952-8Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathyMinjeong Kim0Hyemoon Chung1In-Soo Kim2Chul Hwan Park3Se-Joong Rim4Eui-Young Choi5Division of Cardiology, Myongji Hospital, Hanyang University College of MedicineDivision of Cardiology, Department of Internal Medicine, Kyung Hee University School of MedicineDivision of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of MedicineDivision of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei University College of MedicineDivision of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract Background To investigate the differential contribution of the left atrial (LA) function and left ventricular (LV) fibrosis to pulmonary arterial systolic pressure (PASP) in hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and reperfused acute myocardial infarction (AMI). Methods Data of 370 patients with HCM (n = 133), DCM (n = 114) and reperfused AMI (n = 123) who underwent both echocardiography and cardiovascular magnetic resonance (CMR) were comprehensively reviewed. Phasic LA volumes, LA-global longitudinal strain (GLS), LA stiffness index, defined as E/e′/LA-GLS and extracellular volume fraction (ECV) of LV were measured using CMR. Results E/e′ was correlated with PASP in all groups; however, the predicted value was significantly attenuated after adjusting for LA volume and LA strain in HCM and DCM, but remained significant in AMI. The LA stiffness index was related to PASP in HCM (p = 0.01) and DCM (p = 0.03) independent of LA volume index and E/e′, but not in AMI. In DCM, ECV was significantly related to PASP (p < 0.001) independent of LA volume index and E/e′. When subdivided according to the linear regression between PASP and E/e′, patients in the discrepantly high PASP group had lower total emptying fraction and reservoir fraction of left atrium in HCM and DCM but not in AMI. Conclusions The LA function in HCM and DCM and LV fibrosis in DCM correlated with PASP independent of E/e′ and LA size, contrary to that in AMI. These results suggest the presence of LA dysfunction in non-ischemic cardiomyopathies and usefulness of ECV measurement in DCM for the comprehensive evaluation of LV diastolic function.https://doi.org/10.1186/s12872-022-02952-8Left atrial functionPulmonary artery systolic pressureDilated cardiomyopathyHypertrophic cardiomyopathyAcute myocardial infarction |
| spellingShingle | Minjeong Kim Hyemoon Chung In-Soo Kim Chul Hwan Park Se-Joong Rim Eui-Young Choi Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy BMC Cardiovascular Disorders Left atrial function Pulmonary artery systolic pressure Dilated cardiomyopathy Hypertrophic cardiomyopathy Acute myocardial infarction |
| title | Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy |
| title_full | Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy |
| title_fullStr | Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy |
| title_full_unstemmed | Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy |
| title_short | Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy |
| title_sort | effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction hypertrophic and dilated cardiomyopathy |
| topic | Left atrial function Pulmonary artery systolic pressure Dilated cardiomyopathy Hypertrophic cardiomyopathy Acute myocardial infarction |
| url | https://doi.org/10.1186/s12872-022-02952-8 |
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