Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross...
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2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1329 |
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| author | Diego Santos-García Ariadna Laguna Jorge Hernández-Vara Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Iago García Díaz Silvia Jesús Maria Teresa Boungiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Manuel Menéndez González Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir on behalf of the COPPADIS Study Group |
| author_facet | Diego Santos-García Ariadna Laguna Jorge Hernández-Vara Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Iago García Díaz Silvia Jesús Maria Teresa Boungiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Manuel Menéndez González Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir on behalf of the COPPADIS Study Group |
| author_sort | Diego Santos-García |
| collection | DOAJ |
| description | Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; <i>p</i> = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; <i>p</i> = 0.259). Symptoms such as depression (<i>p</i> < 0.0001), fatigue (<i>p</i> < 0.0001), and pain (<i>p</i> < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (<i>p</i> < 0.0001), speech problems (<i>p</i> < 0.0001), rigidity (<i>p</i> < 0.0001), and hypersexuality (<i>p</i> < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (<i>p</i> = 0.002). Perception of quality of life was generally worse in females (PDQ-39, <i>p</i> = 0.002; EUROHIS-QOL8, <i>p</i> = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (<i>p</i> = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (<i>p</i> = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed. |
| first_indexed | 2024-03-11T08:38:22Z |
| format | Article |
| id | doaj.art-139c2b07d5d443dfa98f0ff8486e8537 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:22Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-139c2b07d5d443dfa98f0ff8486e85372023-11-16T21:18:03ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124132910.3390/jcm12041329Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s DiseaseDiego Santos-García0Ariadna Laguna1Jorge Hernández-Vara2Teresa de Deus Fonticoba3Carlos Cores Bartolomé4Maria J. Feal Painceiras5Maria Cristina Íñiguez-Alvarado6Iago García Díaz7Silvia Jesús8Maria Teresa Boungiorno9Lluís Planellas10Marina Cosgaya11Juan García Caldentey12Nuria Caballol13Ines Legarda14Iria Cabo15Lydia López Manzanares16Isabel González Aramburu17Maria A. Ávila Rivera18Víctor Gómez Mayordomo19Víctor Nogueira20Víctor Puente21Julio Dotor García-Soto22Carmen Borrué23Berta Solano Vila24María Álvarez Sauco25Lydia Vela26Sonia Escalante27Esther Cubo28Francisco Carrillo Padilla29Juan C. Martínez Castrillo30Pilar Sánchez Alonso31Maria G. Alonso Losada32Nuria López Ariztegui33Itziar Gastón34Jaime Kulisevsky35Manuel Menéndez González36Manuel Seijo37Javier Rúiz Martínez38Caridad Valero39Mónica Kurtis40Jessica González Ardura41Ruben Alonso Redondo42Carlos Ordás43Luis M. López Díaz44Darrian McAfee45Pablo Martinez-Martin46Pablo Mir47on behalf of the COPPADIS Study GroupDepartment of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, SpainNeurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR), 08035 Barcelona, SpainNeurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR), 08035 Barcelona, SpainCHUF, Complejo Hospitalario Universitario de Ferrol, 15405 Ferrol, SpainDepartment of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, SpainDepartment of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, SpainDepartment of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, SpainDepartment of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, c/ As Xubias 84, 15006 A Coruña, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, SpainHospital Universitari Mutua de Terrassa, 08221 Terrassa, SpainClínica del Pilar, 50006 Barcelona, SpainHospital Clínic de Barcelona, 08036 Barcelona, SpainCentro Neurológico Oms 42, 07003 Palma de Mallorca, SpainConsorci Sanitari Integral, Hospital Moisés Broggi, 08970 Sant Joan Despí, SpainHospital Universitario Son Espases, 07120 Palma de Mallorca, SpainComplejo Hospitalario Universitario de Pontevedra (CHOP), 36001 Pontevedra, SpainHospital Universitario La Princesa, 28006 Madrid, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, SpainConsorci Sanitari Integral, Hospital General de L’Hospitalet, L’Hospitalet de Llobregat, 08906 Barcelona, SpainHospital Universitario Clínico San Carlos, 28040 Madrid, SpainHospital Da Costa, 27880 Burela, SpainHospital del Mar, 08003 Barcelona, SpainHospital Universitario Virgen Macarena, 41009 Sevilla, SpainHospital Infanta Sofía, 28702 Madrid, SpainInstitut d’Assistència Sanitària (IAS)–Institut Català de la Salut, 17190 Girona, SpainHospital General Universitario de Elche, 03203 Elche, SpainFundación Hospital de Alcorcón, 28922 Madrid, SpainHospital de Tortosa Verge de la Cinta (HTVC), 43500 Tortosa, SpainComplejo Asistencial Universitario de Burgos, 09006 Burgos, SpainHospital Universitario de Canarias, 38320 San Cristóbal de la Laguna, SpainHospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainHospital Universitario Puerta de Hierro, 28222 Madrid, SpainHospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, SpainComplejo Hospitalario de Toledo, 45007 Toledo, SpainComplejo Hospitalario de Navarra, 31008 Pamplona, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, SpainHospital Universitario Central de Asturias, 33011 Oviedo, SpainComplejo Hospitalario Universitario de Pontevedra (CHOP), 36001 Pontevedra, SpainHospital Universitario Donostia, 20014 Donostia, SpainHospital Arnau de Vilanova, 25198 Valencia, SpainHospital Ruber Internacional, 28034 Madrid, SpainHospital de Cabueñes, 33394 Gijón, SpainUniversitario Lucus Augusti (HULA), 27003 Lugo, SpainHospital Rey Juan Carlos, 28933 Madrid, SpainHospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, SpainDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USACIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), 19171 Madrid, SpainBackground and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; <i>p</i> = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; <i>p</i> = 0.259). Symptoms such as depression (<i>p</i> < 0.0001), fatigue (<i>p</i> < 0.0001), and pain (<i>p</i> < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (<i>p</i> < 0.0001), speech problems (<i>p</i> < 0.0001), rigidity (<i>p</i> < 0.0001), and hypersexuality (<i>p</i> < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (<i>p</i> = 0.002). Perception of quality of life was generally worse in females (PDQ-39, <i>p</i> = 0.002; EUROHIS-QOL8, <i>p</i> = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (<i>p</i> = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (<i>p</i> = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.https://www.mdpi.com/2077-0383/12/4/1329motornon-motor symptomsgenderParkinson’s diseasequality of lifesex |
| spellingShingle | Diego Santos-García Ariadna Laguna Jorge Hernández-Vara Teresa de Deus Fonticoba Carlos Cores Bartolomé Maria J. Feal Painceiras Maria Cristina Íñiguez-Alvarado Iago García Díaz Silvia Jesús Maria Teresa Boungiorno Lluís Planellas Marina Cosgaya Juan García Caldentey Nuria Caballol Ines Legarda Iria Cabo Lydia López Manzanares Isabel González Aramburu Maria A. Ávila Rivera Víctor Gómez Mayordomo Víctor Nogueira Víctor Puente Julio Dotor García-Soto Carmen Borrué Berta Solano Vila María Álvarez Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo Padilla Juan C. Martínez Castrillo Pilar Sánchez Alonso Maria G. Alonso Losada Nuria López Ariztegui Itziar Gastón Jaime Kulisevsky Manuel Menéndez González Manuel Seijo Javier Rúiz Martínez Caridad Valero Mónica Kurtis Jessica González Ardura Ruben Alonso Redondo Carlos Ordás Luis M. López Díaz Darrian McAfee Pablo Martinez-Martin Pablo Mir on behalf of the COPPADIS Study Group Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease Journal of Clinical Medicine motor non-motor symptoms gender Parkinson’s disease quality of life sex |
| title | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
| title_full | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
| title_fullStr | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
| title_full_unstemmed | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
| title_short | Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease |
| title_sort | sex differences in motor and non motor symptoms among spanish patients with parkinson s disease |
| topic | motor non-motor symptoms gender Parkinson’s disease quality of life sex |
| url | https://www.mdpi.com/2077-0383/12/4/1329 |
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