The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of Streptococcus suis impacting the transcriptome and virulence in a zebrafish larvae infection model

The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of Streptococcus suis impacting the transcriptome and virulence in a zebrafish larvae infection model

ABSTRACTPhase-variable type I restriction modification (RM) systems are epigenetic regulatory systems that have been identified in numerous human bacterial pathogens. We previously showed that an emerging zoonotic lineage of Streptococcus suis acquired a phase-variable type I RM system, named SsuCC2...

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Bibliographic Details
Main Authors: Thomas J. Roodsant, Boas van der Putten, Jaime Brizuela, Jordy P. M. Coolen, Tim J. H. Baltussen, Kim Schipper, Yvonne Pannekoek, Kees C. H. van der Ark, Constance Schultsz
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
Streptococcus suis
zoonosis
type I restriction modification system
phase-variation
DNA methylation
epigenetic regulation
Online Access:https://journals.asm.org/doi/10.1128/mbio.02259-23

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