Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retros...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/8/2/78 |
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| author | Caterina Beatrice Monti Francesco Secchi Marco Alì Francesco Saverio Carbone Luca Bonomo Davide Capra Nazanin Mobini Giovanni Di Leo Francesco Sardanelli |
| author_facet | Caterina Beatrice Monti Francesco Secchi Marco Alì Francesco Saverio Carbone Luca Bonomo Davide Capra Nazanin Mobini Giovanni Di Leo Francesco Sardanelli |
| author_sort | Caterina Beatrice Monti |
| collection | DOAJ |
| description | In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (<i>p <</i> 0.001 for both), while follow-up and controls did not differ (<i>p =</i> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both <i>p <</i> 0.001), while follow-up and controls did not differ (<i>p =</i> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis. |
| first_indexed | 2024-03-09T04:09:22Z |
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| id | doaj.art-139c56f9c3d84f518c5801c6fec4e809 |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-09T04:09:22Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-139c56f9c3d84f518c5801c6fec4e8092023-12-03T14:01:17ZengMDPI AGTomography2379-13812379-139X2022-04-018297498410.3390/tomography8020078Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis PatientsCaterina Beatrice Monti0Francesco Secchi1Marco Alì2Francesco Saverio Carbone3Luca Bonomo4Davide Capra5Nazanin Mobini6Giovanni Di Leo7Francesco Sardanelli8Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Diagnostic Imaging and Stereotactic Radiosurgery, C.D.I. Centro Diagnostico Italiano S.p.A., 20147 Milan, ItalyCorso di Laurea in Medicina e Chirurgia, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, ItalyCorso di Laurea in Medicina e Chirurgia, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyUnit of Radiology, IRCCS Policlinico San Donato, 20097 San Donato Milanese, ItalyDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, ItalyIn this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0–9.2%) at the acute phase, 4.4% (3.3–7.2%) at follow-up, and 4.3% (3.0–5.3%) in controls, the acute phase being higher than both follow-up and controls (<i>p <</i> 0.001 for both), while follow-up and controls did not differ (<i>p =</i> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4–18.1%) at the acute phase, 7.3% (5.5–8.8%) at follow-up, and 6.7% (5.6–8.6%) in controls, the acute phase being higher than both follow-up and controls (both <i>p <</i> 0.001), while follow-up and controls did not differ (<i>p =</i> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.https://www.mdpi.com/2379-139X/8/2/78myocarditisedemamagnetic resonance imaginggadolinium |
| spellingShingle | Caterina Beatrice Monti Francesco Secchi Marco Alì Francesco Saverio Carbone Luca Bonomo Davide Capra Nazanin Mobini Giovanni Di Leo Francesco Sardanelli Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients Tomography myocarditis edema magnetic resonance imaging gadolinium |
| title | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
| title_full | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
| title_fullStr | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
| title_full_unstemmed | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
| title_short | Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients |
| title_sort | quantitative assessment of late gadolinium enhancement and edema at cardiac magnetic resonance in low risk myocarditis patients |
| topic | myocarditis edema magnetic resonance imaging gadolinium |
| url | https://www.mdpi.com/2379-139X/8/2/78 |
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