Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications
Abstract Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and ea...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-05-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s40820-020-00423-3 |
| _version_ | 1818147881399353344 |
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| author | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan |
| author_facet | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan |
| author_sort | Yujia Sun |
| collection | DOAJ |
| description | Abstract Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. In this review, the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section. Then, state-of-the-art strategies to functionalize MOFs with therapeutic agents were summarized, including surface adsorption, pore encapsulation, covalent binding, and functional molecules as building blocks. In the third section, the most recent biological applications of MOFs for intracellular delivery of drugs, proteins, and nucleic acids, especially aptamers, were presented. Finally, challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. |
| first_indexed | 2024-12-11T12:42:17Z |
| format | Article |
| id | doaj.art-139ce268cf2c4914be398621b3e08de8 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-12-11T12:42:17Z |
| publishDate | 2020-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-139ce268cf2c4914be398621b3e08de82022-12-22T01:06:55ZengSpringerOpenNano-Micro Letters2311-67062150-55512020-05-0112112910.1007/s40820-020-00423-3Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical ApplicationsYujia Sun0Liwei Zheng1Yu Yang2Xu Qian3Ting Fu4Xiaowei Li5Zunyi Yang6He Yan7Cheng Cui8Weihong Tan9Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan UniversityDepartment of Electrical Engineering, Stanford UniversityCenter for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of FloridaInstitute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, The Cancer Hospital of the University of Chinese Academy of SciencesMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan UniversityCenter for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of FloridaFoundation for Applied Molecular EvolutionMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan UniversityMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan UniversityMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan UniversityAbstract Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. In this review, the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section. Then, state-of-the-art strategies to functionalize MOFs with therapeutic agents were summarized, including surface adsorption, pore encapsulation, covalent binding, and functional molecules as building blocks. In the third section, the most recent biological applications of MOFs for intracellular delivery of drugs, proteins, and nucleic acids, especially aptamers, were presented. Finally, challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.http://link.springer.com/article/10.1007/s40820-020-00423-3Metal–organic frameworksDrugsBiomoleculesDrug deliveryBiomedical applications |
| spellingShingle | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications Nano-Micro Letters Metal–organic frameworks Drugs Biomolecules Drug delivery Biomedical applications |
| title | Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications |
| title_full | Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications |
| title_fullStr | Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications |
| title_full_unstemmed | Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications |
| title_short | Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications |
| title_sort | metal organic framework nanocarriers for drug delivery in biomedical applications |
| topic | Metal–organic frameworks Drugs Biomolecules Drug delivery Biomedical applications |
| url | http://link.springer.com/article/10.1007/s40820-020-00423-3 |
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