Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia
Introduction Mild cognitive impairment (MCI) represent a state of cognitive function between normal aging and dementia and does not always progress to dementia. Neuroinflammation has a key role in the pathogenesis of neurodegeneration. Determining the associations of neuroinflammatory markers in th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822004564/type/journal_article |
| _version_ | 1797617621964685312 |
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| author | Y. Zorkina T. Syunyakov A. Andriushchenko O. Abramova M. Kurmishev G. Kostyuk A. Morozova |
| author_facet | Y. Zorkina T. Syunyakov A. Andriushchenko O. Abramova M. Kurmishev G. Kostyuk A. Morozova |
| author_sort | Y. Zorkina |
| collection | DOAJ |
| description |
Introduction
Mild cognitive impairment (MCI) represent a state of cognitive function between normal aging and dementia and does not always progress to dementia. Neuroinflammation has a key role in the pathogenesis of neurodegeneration. Determining the associations of neuroinflammatory markers in the blood with clinical disease severity may be useful for early diagnosis of cognitive impairment and prediction of the development of severe dementia.
Objectives
The aim of our study was to compare the serum concentration of a panel of inflammatory markers in patients with MCI and dementia as well as their associations with clinical symptoms.
Methods
Patients were evaluated using Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT), Montreal Cognitive Assessment scales (MoCA), Clinical Dementia rating (CDR) and Hospital Anxiety Depression Scale (HADS). We determined the serum concentration of a panel of inflammatory markers (25 units) cytokines, chemokines, growth factors and several others on Mulliplex and prepared multivariate analysis to investigate associations between clinical features and serum concentration.
Results
Patients with dementia had lower scores on scales than the control and MCI groups. MCI patients were equal to the control group, except for the MMSE scale. EGF, eotaxin-1, GRO-α, IP-10, IL-8, MIP-1β, sCD40L, TNF-α, MDC and MCP-1, VEGF were differ between groups. Multivariate analysis identified some neuroinflammatory parameters associated with the severity of the disease.
Conclusions
We identified some neuroinflammatory parameters associated with dementia and MCI. Many of them have been poor described and data is contradictory. It is necessary to investigate these parameters as potential biomarkers of neurodegeneration in further studies.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:58:27Z |
| format | Article |
| id | doaj.art-139d6b7ff95443dda0b599a818499090 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:58:27Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-139d6b7ff95443dda0b599a8184990902023-11-17T05:05:14ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S172S17210.1192/j.eurpsy.2022.456Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementiaY. Zorkina0T. Syunyakov1A. Andriushchenko2O. Abramova3M. Kurmishev4G. Kostyuk5A. Morozova6V.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Department Of Basic And Applied Neurobiology, Moscow, Russian Federation Mental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian FederationMental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian FederationMental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian FederationV.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Department Of Basic And Applied Neurobiology, Moscow, Russian FederationMental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian FederationMental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian FederationV.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Department Of Basic And Applied Neurobiology, Moscow, Russian Federation Mental Health Clinic No. 1 named after N. A. Alexeev, Research Center, Moscow, Russian Federation Introduction Mild cognitive impairment (MCI) represent a state of cognitive function between normal aging and dementia and does not always progress to dementia. Neuroinflammation has a key role in the pathogenesis of neurodegeneration. Determining the associations of neuroinflammatory markers in the blood with clinical disease severity may be useful for early diagnosis of cognitive impairment and prediction of the development of severe dementia. Objectives The aim of our study was to compare the serum concentration of a panel of inflammatory markers in patients with MCI and dementia as well as their associations with clinical symptoms. Methods Patients were evaluated using Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT), Montreal Cognitive Assessment scales (MoCA), Clinical Dementia rating (CDR) and Hospital Anxiety Depression Scale (HADS). We determined the serum concentration of a panel of inflammatory markers (25 units) cytokines, chemokines, growth factors and several others on Mulliplex and prepared multivariate analysis to investigate associations between clinical features and serum concentration. Results Patients with dementia had lower scores on scales than the control and MCI groups. MCI patients were equal to the control group, except for the MMSE scale. EGF, eotaxin-1, GRO-α, IP-10, IL-8, MIP-1β, sCD40L, TNF-α, MDC and MCP-1, VEGF were differ between groups. Multivariate analysis identified some neuroinflammatory parameters associated with the severity of the disease. Conclusions We identified some neuroinflammatory parameters associated with dementia and MCI. Many of them have been poor described and data is contradictory. It is necessary to investigate these parameters as potential biomarkers of neurodegeneration in further studies. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822004564/type/journal_articleMoCAMCIMMSEDementia |
| spellingShingle | Y. Zorkina T. Syunyakov A. Andriushchenko O. Abramova M. Kurmishev G. Kostyuk A. Morozova Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia European Psychiatry MoCA MCI MMSE Dementia |
| title | Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| title_full | Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| title_fullStr | Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| title_full_unstemmed | Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| title_short | Associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| title_sort | associations of neuroinflammatory parameters with clinical features in patients with mild cognitive impairment and dementia |
| topic | MoCA MCI MMSE Dementia |
| url | https://www.cambridge.org/core/product/identifier/S0924933822004564/type/journal_article |
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