Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population
The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/11/3389 |
| _version_ | 1797548789648588800 |
|---|---|
| author | María Luisa Maycotte-Cervantes Adriana Aguilar-Galarza Miriam Aracely Anaya-Loyola Ma. de Lourdes Anzures-Cortes Lorenza Haddad-Talancón Akram Sharim Méndez-Rangel Teresa García-Gasca Víctor Manuel Rodríguez-García Ulisses Moreno-Celis |
| author_facet | María Luisa Maycotte-Cervantes Adriana Aguilar-Galarza Miriam Aracely Anaya-Loyola Ma. de Lourdes Anzures-Cortes Lorenza Haddad-Talancón Akram Sharim Méndez-Rangel Teresa García-Gasca Víctor Manuel Rodríguez-García Ulisses Moreno-Celis |
| author_sort | María Luisa Maycotte-Cervantes |
| collection | DOAJ |
| description | The elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with clinical markers of non-communicable chronic diseases in the Mexican population. A sample of 1075 participants was obtained, who underwent clinical, biochemical, and nutritional evaluation, and a genetic evaluation of 91 genetic variants of ELOVL was considered (2–7). The results indicate a 33.16% prevalence of obesity by body mass index, 13.84% prevalence of insulin resistance by homeostatic model assessment (HOMA) index, 7.85% prevalence of high cholesterol, and 20.37% prevalence of hypercholesterolemia. The deprived alleles showed that there is no association between them and clinical disease risk markers, and the notable finding of the association studies is that the ELOVL2 variants are exclusive in men and ELVOL7 in women. There is also a strong association of ELOVL6 with various markers. The present study shows, for the first time, the association between the different ELOVLs and clinical markers of chronic non-communicable diseases. |
| first_indexed | 2024-03-10T15:05:45Z |
| format | Article |
| id | doaj.art-139f12a8692e494c8a141186f7476a1f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:05:45Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-139f12a8692e494c8a141186f7476a1f2023-11-20T19:45:25ZengMDPI AGNutrients2072-66432020-11-011211338910.3390/nu12113389Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican PopulationMaría Luisa Maycotte-Cervantes0Adriana Aguilar-Galarza1Miriam Aracely Anaya-Loyola2Ma. de Lourdes Anzures-Cortes3Lorenza Haddad-Talancón4Akram Sharim Méndez-Rangel5Teresa García-Gasca6Víctor Manuel Rodríguez-García7Ulisses Moreno-Celis8Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, MexicoFacultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, MexicoFacultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, MexicoCódigo 46 SA de CV, Cuernavaca, Morelos 62498, MexicoCódigo 46 SA de CV, Cuernavaca, Morelos 62498, MexicoCódigo 46 SA de CV, Cuernavaca, Morelos 62498, MexicoFacultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, MexicoTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, San Pablo, Querétaro 76130, MexicoFacultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Querétaro CP 76230, MexicoThe elongation of very long chain fatty acids (ELOVL) is a family of seven enzymes that have specific functions in the synthesis of fatty acids. Some have been shown to be related to insulin secretion (ELOVL2), and in the lipid profile (ELOVL6) and patients with various pathologies. The present work focused on the study of ELOVL polymorphs with clinical markers of non-communicable chronic diseases in the Mexican population. A sample of 1075 participants was obtained, who underwent clinical, biochemical, and nutritional evaluation, and a genetic evaluation of 91 genetic variants of ELOVL was considered (2–7). The results indicate a 33.16% prevalence of obesity by body mass index, 13.84% prevalence of insulin resistance by homeostatic model assessment (HOMA) index, 7.85% prevalence of high cholesterol, and 20.37% prevalence of hypercholesterolemia. The deprived alleles showed that there is no association between them and clinical disease risk markers, and the notable finding of the association studies is that the ELOVL2 variants are exclusive in men and ELVOL7 in women. There is also a strong association of ELOVL6 with various markers. The present study shows, for the first time, the association between the different ELOVLs and clinical markers of chronic non-communicable diseases.https://www.mdpi.com/2072-6643/12/11/3389biomarkersELOVLmetabolic alterationsMexican populationSingle Nucleotide Polymorphisms |
| spellingShingle | María Luisa Maycotte-Cervantes Adriana Aguilar-Galarza Miriam Aracely Anaya-Loyola Ma. de Lourdes Anzures-Cortes Lorenza Haddad-Talancón Akram Sharim Méndez-Rangel Teresa García-Gasca Víctor Manuel Rodríguez-García Ulisses Moreno-Celis Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population Nutrients biomarkers ELOVL metabolic alterations Mexican population Single Nucleotide Polymorphisms |
| title | Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population |
| title_full | Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population |
| title_fullStr | Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population |
| title_full_unstemmed | Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population |
| title_short | Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population |
| title_sort | influence of single nucleotide polymorphisms of elovl on biomarkers of metabolic alterations in the mexican population |
| topic | biomarkers ELOVL metabolic alterations Mexican population Single Nucleotide Polymorphisms |
| url | https://www.mdpi.com/2072-6643/12/11/3389 |
| work_keys_str_mv | AT marialuisamaycottecervantes influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT adrianaaguilargalarza influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT miriamaracelyanayaloyola influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT madelourdesanzurescortes influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT lorenzahaddadtalancon influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT akramsharimmendezrangel influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT teresagarciagasca influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT victormanuelrodriguezgarcia influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation AT ulissesmorenocelis influenceofsinglenucleotidepolymorphismsofelovlonbiomarkersofmetabolicalterationsinthemexicanpopulation |