Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure
Heart failure (HF) is a syndrome with global clinical and socioeconomic burden worldwide owing to its poor prognosis. Accumulating evidence has implicated the possible contribution of gut microbiota-derived metabolites, short-chain fatty acids (SCFAs), on the pathology of a variety of diseases. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1805 |
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| author | Midori Yukino-Iwashita Yuji Nagatomo Akane Kawai Akira Taruoka Yusuke Yumita Kazuki Kagami Risako Yasuda Takumi Toya Yukinori Ikegami Nobuyuki Masaki Yasuo Ido Takeshi Adachi |
| author_facet | Midori Yukino-Iwashita Yuji Nagatomo Akane Kawai Akira Taruoka Yusuke Yumita Kazuki Kagami Risako Yasuda Takumi Toya Yukinori Ikegami Nobuyuki Masaki Yasuo Ido Takeshi Adachi |
| author_sort | Midori Yukino-Iwashita |
| collection | DOAJ |
| description | Heart failure (HF) is a syndrome with global clinical and socioeconomic burden worldwide owing to its poor prognosis. Accumulating evidence has implicated the possible contribution of gut microbiota-derived metabolites, short-chain fatty acids (SCFAs), on the pathology of a variety of diseases. The changes of SCFA concentration were reported to be observed in various cardiovascular diseases including HF in experimental animals and humans. HF causes hypoperfusion and/or congestion in the gut, which may lead to lowered production of SCFAs, possibly through the pathological changes of the gut microenvironment including microbiota composition. Recent studies suggest that SCFAs may play a significant role in the pathology of HF, possibly through an agonistic effect on G-protein-coupled receptors, histone deacetylases (HDACs) inhibition, restoration of mitochondrial function, amelioration of cardiac inflammatory response, its utilization as an energy source, and remote effect attributable to a protective effect on the other organs. Collectively, in the pathology of HF, SCFAs might play a significant role as a key mediator in the gut–heart axis. However, these possible mechanisms have not been entirely clarified and need further investigation. |
| first_indexed | 2024-03-09T18:56:24Z |
| format | Article |
| id | doaj.art-13a099fc488e43c7b7e1e17adfe5d455 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:56:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-13a099fc488e43c7b7e1e17adfe5d4552023-11-24T05:25:28ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011211180510.3390/jpm12111805Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart FailureMidori Yukino-Iwashita0Yuji Nagatomo1Akane Kawai2Akira Taruoka3Yusuke Yumita4Kazuki Kagami5Risako Yasuda6Takumi Toya7Yukinori Ikegami8Nobuyuki Masaki9Yasuo Ido10Takeshi Adachi11Department of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, JapanHeart failure (HF) is a syndrome with global clinical and socioeconomic burden worldwide owing to its poor prognosis. Accumulating evidence has implicated the possible contribution of gut microbiota-derived metabolites, short-chain fatty acids (SCFAs), on the pathology of a variety of diseases. The changes of SCFA concentration were reported to be observed in various cardiovascular diseases including HF in experimental animals and humans. HF causes hypoperfusion and/or congestion in the gut, which may lead to lowered production of SCFAs, possibly through the pathological changes of the gut microenvironment including microbiota composition. Recent studies suggest that SCFAs may play a significant role in the pathology of HF, possibly through an agonistic effect on G-protein-coupled receptors, histone deacetylases (HDACs) inhibition, restoration of mitochondrial function, amelioration of cardiac inflammatory response, its utilization as an energy source, and remote effect attributable to a protective effect on the other organs. Collectively, in the pathology of HF, SCFAs might play a significant role as a key mediator in the gut–heart axis. However, these possible mechanisms have not been entirely clarified and need further investigation.https://www.mdpi.com/2075-4426/12/11/1805short-chain fatty acidacetatebutyratepropionatehistone deacetylasesG-protein-coupled receptors |
| spellingShingle | Midori Yukino-Iwashita Yuji Nagatomo Akane Kawai Akira Taruoka Yusuke Yumita Kazuki Kagami Risako Yasuda Takumi Toya Yukinori Ikegami Nobuyuki Masaki Yasuo Ido Takeshi Adachi Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure Journal of Personalized Medicine short-chain fatty acid acetate butyrate propionate histone deacetylases G-protein-coupled receptors |
| title | Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure |
| title_full | Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure |
| title_fullStr | Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure |
| title_full_unstemmed | Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure |
| title_short | Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure |
| title_sort | short chain fatty acids in gut heart axis their role in the pathology of heart failure |
| topic | short-chain fatty acid acetate butyrate propionate histone deacetylases G-protein-coupled receptors |
| url | https://www.mdpi.com/2075-4426/12/11/1805 |
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