Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology
Objective: To optimize the ionic liquid based microwave-assisted extraction (IL-MAE) of polyphenolic content from Peperomia pellucida (L) Kunth. Methods: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration, and liquid–solid rat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-07-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169117305117 |
| _version_ | 1819019174839582720 |
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| author | Islamudin Ahmad Arry Yanuar Kamarza Mulia Abdul Mun'im |
| author_facet | Islamudin Ahmad Arry Yanuar Kamarza Mulia Abdul Mun'im |
| author_sort | Islamudin Ahmad |
| collection | DOAJ |
| description | Objective: To optimize the ionic liquid based microwave-assisted extraction (IL-MAE) of polyphenolic content from Peperomia pellucida (L) Kunth.
Methods: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration, and liquid–solid ratio had been involved. Response surface methodology and Box–Behnken design were used to obtain predictive model (multivariate quadratic regression equation) and optimization of the extraction process. The response surface was analyzed by using the yields of total polyphenolic content as response value.
Results: Based on the obtained results the optimum extraction condition, including microwave power of 30% Watts, extraction time of 18.5 min, the ionic liquid concentration of 0.79 mol/L, and the liquid–solid ratio of 10.72 mL/g 1-Buthyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) as a solvent was selected. The regression model was obtained to predicts the yields from Peperomia pellucida: Y = 30.250 – 1.356X1 + 2.655X2 + 2.252X3 – 0.565X4 + 0.990 X1X3 – 8.172 X1X4 – 3.439 X3X4 – 4.178 X12 – 3.210 X32 – 6.786 X42 – 7.290 X12X3 + 5.575 X1X32 – 4.843 X32X4 with R2 = 0.82519. Scale-up confirmation test was obtained the maximum yields of total polyphenolics content with the amount of 31.172 5 μg GAE/g.
Conclusions: The IL-MAE method produced a higher extraction polyphenolic and performed rapidly, easily and efficiently. |
| first_indexed | 2024-12-21T03:31:08Z |
| format | Article |
| id | doaj.art-13a20fcce66646a9bff081abb6dc4aba |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-21T03:31:08Z |
| publishDate | 2017-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-13a20fcce66646a9bff081abb6dc4aba2022-12-21T19:17:28ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912017-07-017766066510.1016/j.apjtb.2017.06.010Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodologyIslamudin Ahmad0Arry Yanuar1Kamarza Mulia2Abdul Mun'im3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mulawarman University, Samarinda, East Kalimantan, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424 West Java, IndonesiaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, IndonesiaObjective: To optimize the ionic liquid based microwave-assisted extraction (IL-MAE) of polyphenolic content from Peperomia pellucida (L) Kunth. Methods: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration, and liquid–solid ratio had been involved. Response surface methodology and Box–Behnken design were used to obtain predictive model (multivariate quadratic regression equation) and optimization of the extraction process. The response surface was analyzed by using the yields of total polyphenolic content as response value. Results: Based on the obtained results the optimum extraction condition, including microwave power of 30% Watts, extraction time of 18.5 min, the ionic liquid concentration of 0.79 mol/L, and the liquid–solid ratio of 10.72 mL/g 1-Buthyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) as a solvent was selected. The regression model was obtained to predicts the yields from Peperomia pellucida: Y = 30.250 – 1.356X1 + 2.655X2 + 2.252X3 – 0.565X4 + 0.990 X1X3 – 8.172 X1X4 – 3.439 X3X4 – 4.178 X12 – 3.210 X32 – 6.786 X42 – 7.290 X12X3 + 5.575 X1X32 – 4.843 X32X4 with R2 = 0.82519. Scale-up confirmation test was obtained the maximum yields of total polyphenolics content with the amount of 31.172 5 μg GAE/g. Conclusions: The IL-MAE method produced a higher extraction polyphenolic and performed rapidly, easily and efficiently.http://www.sciencedirect.com/science/article/pii/S2221169117305117Peperomia pellucida (L) Kunth1-buthyl-3-methylimidazoliumTetrafluoroborateResponse surface methodologyBox–Behnken designPolyphenolic content |
| spellingShingle | Islamudin Ahmad Arry Yanuar Kamarza Mulia Abdul Mun'im Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology Asian Pacific Journal of Tropical Biomedicine Peperomia pellucida (L) Kunth 1-buthyl-3-methylimidazolium Tetrafluoroborate Response surface methodology Box–Behnken design Polyphenolic content |
| title | Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology |
| title_full | Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology |
| title_fullStr | Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology |
| title_full_unstemmed | Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology |
| title_short | Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology |
| title_sort | optimization of ionic liquid based microwave assisted extraction of polyphenolic content from peperomia pellucida l kunth using response surface methodology |
| topic | Peperomia pellucida (L) Kunth 1-buthyl-3-methylimidazolium Tetrafluoroborate Response surface methodology Box–Behnken design Polyphenolic content |
| url | http://www.sciencedirect.com/science/article/pii/S2221169117305117 |
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