Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines

Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines

Abstract Background One of the major challenges to leishmaniasis treatment is the emergence of parasites resistant to antimony. To study differentially expressed genes associated with drug resistance, we performed a comparative transcriptomic analysis between wild-type and potassium antimonyl tartra...

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Main Authors: Juvana Moreira Andrade, Leilane Oliveira Gonçalves, Daniel Barbosa Liarte, Davi Alvarenga Lima, Frederico Gonçalves Guimarães, Daniela de Melo Resende, Ana Maria Murta Santi, Luciana Marcia de Oliveira, João Paulo Linhares Velloso, Renato Guimarães Delfino, Pascale Pescher, Gerald F. Späth, Jeronimo Conceição Ruiz, Silvane Maria Fonseca Murta
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Parasites & Vectors
Subjects:
Leishmania infantum
Trivalent antimony
Resistance
RNA sequencing
Transcriptome
Differentially expressed genes
Online Access:https://doi.org/10.1186/s13071-020-04486-4

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