Recent progress of microfluidic chips in immunoassay
Microfluidic chip technology is a technology platform that integrates basic operation units such as processing, separation, reaction and detection into microchannel chip to realize low consumption, fast and efficient analysis of samples. It has the characteristics of small volume need of samples and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1112327/full |
| _version_ | 1797978610169020416 |
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| author | Kaimin Wu Xuliang He Jinglei Wang Ting Pan Ran He Feizhi Kong Zhenmin Cao Feiye Ju Zhao Huang Libo Nie |
| author_facet | Kaimin Wu Xuliang He Jinglei Wang Ting Pan Ran He Feizhi Kong Zhenmin Cao Feiye Ju Zhao Huang Libo Nie |
| author_sort | Kaimin Wu |
| collection | DOAJ |
| description | Microfluidic chip technology is a technology platform that integrates basic operation units such as processing, separation, reaction and detection into microchannel chip to realize low consumption, fast and efficient analysis of samples. It has the characteristics of small volume need of samples and reagents, fast analysis, low cost, automation, portability, high throughout, and good compatibility with other techniques. In this review, the concept, preparation materials and fabrication technology of microfluidic chip are described. The applications of microfluidic chip in immunoassay, including fluorescent, chemiluminescent, surface-enhanced Raman spectroscopy (SERS), and electrochemical immunoassay are reviewed. Look into the future, the development of microfluidic chips lies in point-of-care testing and high throughput equipment, and there are still some challenges in the design and the integration of microfluidic chips, as well as the analysis of actual sample by microfluidic chips. |
| first_indexed | 2024-04-11T05:25:42Z |
| format | Article |
| id | doaj.art-13a3e87bf0514b5f8f28d6ab4a7ea817 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T05:25:42Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-13a3e87bf0514b5f8f28d6ab4a7ea8172022-12-23T06:37:26ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.11123271112327Recent progress of microfluidic chips in immunoassayKaimin Wu0Xuliang He1Jinglei Wang2Ting Pan3Ran He4Feizhi Kong5Zhenmin Cao6Feiye Ju7Zhao Huang8Libo Nie9Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaZhuzhou People’s Hospital, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, ChinaMicrofluidic chip technology is a technology platform that integrates basic operation units such as processing, separation, reaction and detection into microchannel chip to realize low consumption, fast and efficient analysis of samples. It has the characteristics of small volume need of samples and reagents, fast analysis, low cost, automation, portability, high throughout, and good compatibility with other techniques. In this review, the concept, preparation materials and fabrication technology of microfluidic chip are described. The applications of microfluidic chip in immunoassay, including fluorescent, chemiluminescent, surface-enhanced Raman spectroscopy (SERS), and electrochemical immunoassay are reviewed. Look into the future, the development of microfluidic chips lies in point-of-care testing and high throughput equipment, and there are still some challenges in the design and the integration of microfluidic chips, as well as the analysis of actual sample by microfluidic chips.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1112327/fullmicrofluidic chipimmunoassayfluorescencechemiluminescencesurface-enhanced Raman spectroscopyelectrochemistry |
| spellingShingle | Kaimin Wu Xuliang He Jinglei Wang Ting Pan Ran He Feizhi Kong Zhenmin Cao Feiye Ju Zhao Huang Libo Nie Recent progress of microfluidic chips in immunoassay Frontiers in Bioengineering and Biotechnology microfluidic chip immunoassay fluorescence chemiluminescence surface-enhanced Raman spectroscopy electrochemistry |
| title | Recent progress of microfluidic chips in immunoassay |
| title_full | Recent progress of microfluidic chips in immunoassay |
| title_fullStr | Recent progress of microfluidic chips in immunoassay |
| title_full_unstemmed | Recent progress of microfluidic chips in immunoassay |
| title_short | Recent progress of microfluidic chips in immunoassay |
| title_sort | recent progress of microfluidic chips in immunoassay |
| topic | microfluidic chip immunoassay fluorescence chemiluminescence surface-enhanced Raman spectroscopy electrochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1112327/full |
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