Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity
Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg)....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.798214/full |
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| author | Theodore J. Kottom Theodore J. Kottom Eva M. Carmona Eva M. Carmona Andrew H. Limper Andrew H. Limper |
| author_facet | Theodore J. Kottom Theodore J. Kottom Eva M. Carmona Eva M. Carmona Andrew H. Limper Andrew H. Limper |
| author_sort | Theodore J. Kottom |
| collection | DOAJ |
| description | Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions. |
| first_indexed | 2024-12-21T00:04:02Z |
| format | Article |
| id | doaj.art-13a4769e060a4324841ae0166d5e09f4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T00:04:02Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-13a4769e060a4324841ae0166d5e09f42022-12-21T19:22:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.798214798214Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate ImmunityTheodore J. Kottom0Theodore J. Kottom1Eva M. Carmona2Eva M. Carmona3Andrew H. Limper4Andrew H. Limper5Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, Mayo Clinic, Rochester, MN, United StatesDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United StatesThoracic Diseases Research Unit, Departments of Medicine and Biochemistry, Mayo Clinic, Rochester, MN, United StatesDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United StatesThoracic Diseases Research Unit, Departments of Medicine and Biochemistry, Mayo Clinic, Rochester, MN, United StatesDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United StatesPneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.https://www.frontiersin.org/articles/10.3389/fimmu.2021.798214/fullbeta-glucansCLRinflammationPneumocystispneumonia |
| spellingShingle | Theodore J. Kottom Theodore J. Kottom Eva M. Carmona Eva M. Carmona Andrew H. Limper Andrew H. Limper Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity Frontiers in Immunology beta-glucans CLR inflammation Pneumocystis pneumonia |
| title | Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity |
| title_full | Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity |
| title_fullStr | Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity |
| title_full_unstemmed | Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity |
| title_short | Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity |
| title_sort | current state of carbohydrate recognition and c type lectin receptors in pneumocystis innate immunity |
| topic | beta-glucans CLR inflammation Pneumocystis pneumonia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.798214/full |
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