Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3′-Phosphoadenosine 5′-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the primary enzyme to generate the universal sulfonate donor PAPS. The involvement of PAPSS2-mediated sulfation in ad...

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Bibliographic Details
Main Authors: Pengfei Xu, Yue Xi, Jong-Won Kim, Junjie Zhu, Min Zhang, Meishu Xu, Songrong Ren, Da Yang, Xiaochao Ma, Wen Xie
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Colon cancer
APC
Wnt/β-catenin
PAPSS2
Chondroitin sulfate
Sulfation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523004756

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