The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children

The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children

The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Pro...

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Bibliographic Details
Main Authors: Małgorzata Mizerska-Wasiak, Agnieszka Such-Gruchot, Karolina Cichoń-Kawa, Agnieszka Turczyn, Jadwiga Małdyk, Monika Miklaszewska, Dorota Drożdż, Agnieszka Firszt-Adamczyk, Roman Stankiewicz, Agnieszka Rybi-Szumińska, Anna Wasilewska, Maria Szczepańska, Beata Bieniaś, Przemysław Sikora, Agnieszka Pukajło-Marczyk, Danuta Zwolińska, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Jacek Zachwieja, Magdalena Drożyńska-Duklas, Aleksandra Żurowska, Katarzyna Gadomska-Prokop, Ryszard Grenda, Małgorzata Pańczyk-Tomaszewska
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
IgA nephropathy
complement C3
children
Online Access:https://www.mdpi.com/2077-0383/10/19/4405
Description
Summary:The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children.
ISSN:2077-0383

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