Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study
In this article, we analyze time dependent protein expression data obtained from a proteome study of a neuroblastoma cell line. Neuroblastoma are common solid tumors which occur in early childhood. The expression data was obtained by difference gel electrophoresis (DIGE). It is known that the clini...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Nacional de Estatística | Statistics Portugal
2006-03-01
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| Series: | Revstat Statistical Journal |
| Subjects: | |
| Online Access: | https://revstat.ine.pt/index.php/REVSTAT/article/view/27 |
| _version_ | 1818513125385699328 |
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| author | Klaus Jung Ali Gannoun Barbara Sitek Ognjan Apostolov Alexander Schramm Helmut E. Meyer Kai Stühler Wolfgang Urfer |
| author_facet | Klaus Jung Ali Gannoun Barbara Sitek Ognjan Apostolov Alexander Schramm Helmut E. Meyer Kai Stühler Wolfgang Urfer |
| author_sort | Klaus Jung |
| collection | DOAJ |
| description |
In this article, we analyze time dependent protein expression data obtained from a proteome study of a neuroblastoma cell line. Neuroblastoma are common solid tumors which occur in early childhood. The expression data was obtained by difference gel electrophoresis (DIGE). It is known that the clinical outcome of neuroblastoma depends on the activation of different neurotrophin receptors by their ligands. Here, we are looking for proteome changes resulting from the activation of Tyrosine Kinase (TrkA) receptors by their ligand NGF (nerve growth factor). Before analyzing the data by longitudinal data analysis we do data preprocessing and apply a method for the imputation of missing values.
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| first_indexed | 2024-12-10T23:56:46Z |
| format | Article |
| id | doaj.art-13a6befd07044f74934e3e2bd9d7db6a |
| institution | Directory Open Access Journal |
| issn | 1645-6726 2183-0371 |
| language | English |
| last_indexed | 2024-12-10T23:56:46Z |
| publishDate | 2006-03-01 |
| publisher | Instituto Nacional de Estatística | Statistics Portugal |
| record_format | Article |
| series | Revstat Statistical Journal |
| spelling | doaj.art-13a6befd07044f74934e3e2bd9d7db6a2022-12-22T01:28:34ZengInstituto Nacional de Estatística | Statistics PortugalRevstat Statistical Journal1645-67262183-03712006-03-014110.57805/revstat.v4i1.27Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor StudyKlaus Jung 0Ali Gannoun 1Barbara Sitek 2Ognjan Apostolov 3Alexander Schramm Helmut E. Meyer 4Kai Stühler 5Wolfgang Urfer 6University of DortmundUniversité MontpellierRuhr-University BochumRuhr-University BochumRuhr-University BochumRuhr-University BochumUniversity of Dortmund In this article, we analyze time dependent protein expression data obtained from a proteome study of a neuroblastoma cell line. Neuroblastoma are common solid tumors which occur in early childhood. The expression data was obtained by difference gel electrophoresis (DIGE). It is known that the clinical outcome of neuroblastoma depends on the activation of different neurotrophin receptors by their ligands. Here, we are looking for proteome changes resulting from the activation of Tyrosine Kinase (TrkA) receptors by their ligand NGF (nerve growth factor). Before analyzing the data by longitudinal data analysis we do data preprocessing and apply a method for the imputation of missing values. https://revstat.ine.pt/index.php/REVSTAT/article/view/27protein expression dataproteomedata preprocessingmissing values imputationlongitudinal data analysisneuroblastoma |
| spellingShingle | Klaus Jung Ali Gannoun Barbara Sitek Ognjan Apostolov Alexander Schramm Helmut E. Meyer Kai Stühler Wolfgang Urfer Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study Revstat Statistical Journal protein expression data proteome data preprocessing missing values imputation longitudinal data analysis neuroblastoma |
| title | Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study |
| title_full | Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study |
| title_fullStr | Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study |
| title_full_unstemmed | Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study |
| title_short | Statistical Evaluation of Methods for the Analysis of Dynamic Protein Expression Data From a Tumor Study |
| title_sort | statistical evaluation of methods for the analysis of dynamic protein expression data from a tumor study |
| topic | protein expression data proteome data preprocessing missing values imputation longitudinal data analysis neuroblastoma |
| url | https://revstat.ine.pt/index.php/REVSTAT/article/view/27 |
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