Age-related exacerbation of lung damage after trauma is associated with increased expression of inflammasome components

Age-related exacerbation of lung damage after trauma is associated with increased expression of inflammasome components

BackgroundTrauma, a significant global cause of mortality and disability, often leads to fractures and hemorrhagic shock, initiating an exaggerated inflammatory response, which harms distant organs, particularly the lungs. Elderly individuals are more vulnerable to immune dysregulation post-trauma,...

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Bibliographic Details
Main Authors: Yuzhuo Zhou, Fanshuai Meng, Kernt Köhler, Jasmin Maria Bülow, Alessa Wagner, Claudia Neunaber, Katrin Bundkirchen, Borna Relja
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
femur fracture
hemorrhagic shock
aging
pulmonary injury
inflammasome
NF-KappaB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253637/full

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