Chemical Conjugation in Drug Delivery Systems
Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usually so intense and invasive that they weaken the patient to cure as dangerous as the own disease. From some time ago until today, to reduce resistance generated by the constant administration of the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.889083/full |
| _version_ | 1828781624834129920 |
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| author | Alexis Eras Danna Castillo Margarita Suárez Nelson Santiago Vispo Fernando Albericio Fernando Albericio Fernando Albericio Hortensia Rodriguez |
| author_facet | Alexis Eras Danna Castillo Margarita Suárez Nelson Santiago Vispo Fernando Albericio Fernando Albericio Fernando Albericio Hortensia Rodriguez |
| author_sort | Alexis Eras |
| collection | DOAJ |
| description | Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usually so intense and invasive that they weaken the patient to cure as dangerous as the own disease. From some time ago until today, to reduce resistance generated by the constant administration of the drug and improve its pharmacokinetics, scientists have been developing drug delivery system (DDS) technology. DDS platforms aim to maximize the drugs’ effectiveness by directing them to reach the affected area by the disease and, therefore, reduce the potential side effects. Erythrocytes, antibodies, and nanoparticles have been used as carriers. Eleven antibody–drug conjugates (ADCs) involving covalent linkage has been commercialized as a promising cancer treatment in the last years. This review describes the general features and applications of DDS focused on the covalent conjugation system that binds the antibody carrier to the cytotoxic drug. |
| first_indexed | 2024-12-11T17:37:12Z |
| format | Article |
| id | doaj.art-13a79aa1f9374faeb8a49e4d2477fb7a |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-11T17:37:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-13a79aa1f9374faeb8a49e4d2477fb7a2022-12-22T00:56:38ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-05-011010.3389/fchem.2022.889083889083Chemical Conjugation in Drug Delivery SystemsAlexis Eras0Danna Castillo1Margarita Suárez2Nelson Santiago Vispo3Fernando Albericio4Fernando Albericio5Fernando Albericio6Hortensia Rodriguez7School of Chemical Sciences and Engineering, Yachay Tech University, Urcuquí, EcuadorSchool of Chemical Sciences and Engineering, Yachay Tech University, Urcuquí, EcuadorLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, La Habana, CubaSchool of Biological Sciences and Engineering, Yachay Tech University, Urcuquí, EcuadorDepartment of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, SpainCIBER-BBN, Networking Centre of Bioengineering, Biomaterials, and Nanomedicine and Department of Organic Chemistry, University of Barcelona, Barcelona, SpainSchool of Chemistry and Physics, University of KwaZulu-Natal, Durban, South AfricaSchool of Chemical Sciences and Engineering, Yachay Tech University, Urcuquí, EcuadorCancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usually so intense and invasive that they weaken the patient to cure as dangerous as the own disease. From some time ago until today, to reduce resistance generated by the constant administration of the drug and improve its pharmacokinetics, scientists have been developing drug delivery system (DDS) technology. DDS platforms aim to maximize the drugs’ effectiveness by directing them to reach the affected area by the disease and, therefore, reduce the potential side effects. Erythrocytes, antibodies, and nanoparticles have been used as carriers. Eleven antibody–drug conjugates (ADCs) involving covalent linkage has been commercialized as a promising cancer treatment in the last years. This review describes the general features and applications of DDS focused on the covalent conjugation system that binds the antibody carrier to the cytotoxic drug.https://www.frontiersin.org/articles/10.3389/fchem.2022.889083/fulldrug delivery systemsbiomoleculescarrierscovalent bioconjugationlinkers |
| spellingShingle | Alexis Eras Danna Castillo Margarita Suárez Nelson Santiago Vispo Fernando Albericio Fernando Albericio Fernando Albericio Hortensia Rodriguez Chemical Conjugation in Drug Delivery Systems Frontiers in Chemistry drug delivery systems biomolecules carriers covalent bioconjugation linkers |
| title | Chemical Conjugation in Drug Delivery Systems |
| title_full | Chemical Conjugation in Drug Delivery Systems |
| title_fullStr | Chemical Conjugation in Drug Delivery Systems |
| title_full_unstemmed | Chemical Conjugation in Drug Delivery Systems |
| title_short | Chemical Conjugation in Drug Delivery Systems |
| title_sort | chemical conjugation in drug delivery systems |
| topic | drug delivery systems biomolecules carriers covalent bioconjugation linkers |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.889083/full |
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