Circular RNAs in Breast Cancer: An Update
Breast cancer (BC), characterized by high heterogeneity, is the most commonly reported malignancy among females across the globe. Every year, many BC patients die owing to delayed diagnosis and treatment. Increasing researches have indicated that aberrantly expressed circular RNAs (circRNAs) are imp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/2/158 |
| _version_ | 1797298739004571648 |
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| author | Haolin Bao Jiehan Li Qihang Zhao Qingling Yang Yi Xu |
| author_facet | Haolin Bao Jiehan Li Qihang Zhao Qingling Yang Yi Xu |
| author_sort | Haolin Bao |
| collection | DOAJ |
| description | Breast cancer (BC), characterized by high heterogeneity, is the most commonly reported malignancy among females across the globe. Every year, many BC patients die owing to delayed diagnosis and treatment. Increasing researches have indicated that aberrantly expressed circular RNAs (circRNAs) are implicated in the tumorigenesis and progression of various tumors, including BC. Hence, this article provides a summary of the biogenesis and functions of circRNAs, as well as an examination of how circRNAs regulate the progression of BC. Moreover, circRNAs have aroused incremental attention as potential diagnostic and prognostic biomarkers for BC. Exosomes enriched with circRNAs can be secreted into the tumor microenvironment to mediate intercellular communication, affecting the progression of BC. Detecting the expression levels of exosomal circRNAs may provide reference for BC diagnosis and prognosis prediction. Illuminating insights into the earlier diagnosis and better treatment regimens of BC will be potentially available following elucidation of deeper regulatory mechanisms of circRNAs in this malignancy. |
| first_indexed | 2024-03-07T22:40:20Z |
| format | Article |
| id | doaj.art-13a81d444275419f882364678d111bb2 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:40:20Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-13a81d444275419f882364678d111bb22024-02-23T15:09:15ZengMDPI AGBiomolecules2218-273X2024-01-0114215810.3390/biom14020158Circular RNAs in Breast Cancer: An UpdateHaolin Bao0Jiehan Li1Qihang Zhao2Qingling Yang3Yi Xu4Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Mammary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaAnhui Province Key Laboratory of Cancer Translational Medicine, Bengbu Medical University, Bengbu 233030, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaBreast cancer (BC), characterized by high heterogeneity, is the most commonly reported malignancy among females across the globe. Every year, many BC patients die owing to delayed diagnosis and treatment. Increasing researches have indicated that aberrantly expressed circular RNAs (circRNAs) are implicated in the tumorigenesis and progression of various tumors, including BC. Hence, this article provides a summary of the biogenesis and functions of circRNAs, as well as an examination of how circRNAs regulate the progression of BC. Moreover, circRNAs have aroused incremental attention as potential diagnostic and prognostic biomarkers for BC. Exosomes enriched with circRNAs can be secreted into the tumor microenvironment to mediate intercellular communication, affecting the progression of BC. Detecting the expression levels of exosomal circRNAs may provide reference for BC diagnosis and prognosis prediction. Illuminating insights into the earlier diagnosis and better treatment regimens of BC will be potentially available following elucidation of deeper regulatory mechanisms of circRNAs in this malignancy.https://www.mdpi.com/2218-273X/14/2/158circular RNAbreast cancerbiomarkertreatmentexosome |
| spellingShingle | Haolin Bao Jiehan Li Qihang Zhao Qingling Yang Yi Xu Circular RNAs in Breast Cancer: An Update Biomolecules circular RNA breast cancer biomarker treatment exosome |
| title | Circular RNAs in Breast Cancer: An Update |
| title_full | Circular RNAs in Breast Cancer: An Update |
| title_fullStr | Circular RNAs in Breast Cancer: An Update |
| title_full_unstemmed | Circular RNAs in Breast Cancer: An Update |
| title_short | Circular RNAs in Breast Cancer: An Update |
| title_sort | circular rnas in breast cancer an update |
| topic | circular RNA breast cancer biomarker treatment exosome |
| url | https://www.mdpi.com/2218-273X/14/2/158 |
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