Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes
Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different...
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KeAi Communications Co., Ltd.
2023-05-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235230422200191X |
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| author | Hong-Yang Luo Jie-Ying Zhu Min Chen Wang-Jing Mu Liang Guo |
| author_facet | Hong-Yang Luo Jie-Ying Zhu Min Chen Wang-Jing Mu Liang Guo |
| author_sort | Hong-Yang Luo |
| collection | DOAJ |
| description | Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different cell types, and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling, KLF10 is involved in various biological functions, including glucose and lipid metabolism in liver and adipose tissue, the maintenance of mitochondrial structure and function of the skeletal muscle, cell proliferation and apoptosis, and plays roles in multiple disease processes, such as nonalcoholic steatohepatitis (NASH) and tumor. Besides, KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review, the biological functions of KLF10 and its roles in disease states is updated and discussed, which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10. |
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| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T03:24:41Z |
| publishDate | 2023-05-01 |
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| series | Genes and Diseases |
| spelling | doaj.art-13aa36b12de7477c9485e708ee57d72d2023-09-03T13:38:58ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-05-01103915930Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processesHong-Yang Luo0Jie-Ying Zhu1Min Chen2Wang-Jing Mu3Liang Guo4Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; Corresponding author. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different cell types, and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling, KLF10 is involved in various biological functions, including glucose and lipid metabolism in liver and adipose tissue, the maintenance of mitochondrial structure and function of the skeletal muscle, cell proliferation and apoptosis, and plays roles in multiple disease processes, such as nonalcoholic steatohepatitis (NASH) and tumor. Besides, KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review, the biological functions of KLF10 and its roles in disease states is updated and discussed, which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.http://www.sciencedirect.com/science/article/pii/S235230422200191XAdipose tissueEstrogen signalingGlucose and lipid metabolismNASHObesitySkeletal muscle |
| spellingShingle | Hong-Yang Luo Jie-Ying Zhu Min Chen Wang-Jing Mu Liang Guo Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes Genes and Diseases Adipose tissue Estrogen signaling Glucose and lipid metabolism NASH Obesity Skeletal muscle |
| title | Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes |
| title_full | Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes |
| title_fullStr | Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes |
| title_full_unstemmed | Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes |
| title_short | Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes |
| title_sort | kruppel like factor 10 klf10 as a critical signaling mediator versatile functions in physiological and pathophysiological processes |
| topic | Adipose tissue Estrogen signaling Glucose and lipid metabolism NASH Obesity Skeletal muscle |
| url | http://www.sciencedirect.com/science/article/pii/S235230422200191X |
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