A novel approach to treating osteoarthrosis as a chronic inflammatory disease
A large role in the pathogenesis of osteoarthrosis (OA) is assigned to proinflammatory cytokines, such as interleukin 1 (IL1) and tumor necrosis factor-α, which activate catabolic processes in the cartilaginous tissue and subchondral bone. Diacerein is a medication that is able to block IL1 receptor...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2013-06-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/488 |
| _version_ | 1826556949507866624 |
|---|---|
| author | Rimma Mikhailovna Balabanova |
| author_facet | Rimma Mikhailovna Balabanova |
| author_sort | Rimma Mikhailovna Balabanova |
| collection | DOAJ |
| description | A large role in the pathogenesis of osteoarthrosis (OA) is assigned to proinflammatory cytokines, such as interleukin 1 (IL1) and tumor necrosis factor-α, which activate catabolic processes in the cartilaginous tissue and subchondral bone. Diacerein is a medication that is able to block IL1 receptors, to lower the activity of metalloproteinases and nitric oxide, and thus to prevent joint inflammation and destruction in OA. |
| first_indexed | 2024-04-10T02:07:05Z |
| format | Article |
| id | doaj.art-13aaeef7b8c0416c8bf8f42f82757fbf |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2025-03-14T08:20:50Z |
| publishDate | 2013-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-13aaeef7b8c0416c8bf8f42f82757fbf2025-03-02T13:10:56ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2013-06-0172959810.14412/1996-7012-2013-23901793A novel approach to treating osteoarthrosis as a chronic inflammatory diseaseRimma Mikhailovna BalabanovaA large role in the pathogenesis of osteoarthrosis (OA) is assigned to proinflammatory cytokines, such as interleukin 1 (IL1) and tumor necrosis factor-α, which activate catabolic processes in the cartilaginous tissue and subchondral bone. Diacerein is a medication that is able to block IL1 receptors, to lower the activity of metalloproteinases and nitric oxide, and thus to prevent joint inflammation and destruction in OA.https://mrj.ima-press.net/mrj/article/view/488osteoporosisdiacerein |
| spellingShingle | Rimma Mikhailovna Balabanova A novel approach to treating osteoarthrosis as a chronic inflammatory disease Современная ревматология osteoporosis diacerein |
| title | A novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| title_full | A novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| title_fullStr | A novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| title_full_unstemmed | A novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| title_short | A novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| title_sort | novel approach to treating osteoarthrosis as a chronic inflammatory disease |
| topic | osteoporosis diacerein |
| url | https://mrj.ima-press.net/mrj/article/view/488 |
| work_keys_str_mv | AT rimmamikhailovnabalabanova anovelapproachtotreatingosteoarthrosisasachronicinflammatorydisease AT rimmamikhailovnabalabanova novelapproachtotreatingosteoarthrosisasachronicinflammatorydisease |