Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression

Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression

Endoplasmic reticulum (ER) stress that disrupts ER function can occur in response to a wide variety of cellular stress factors leads to the accumulation of unfolded and misfolded proteins in the ER. Many studies have shown that ER stress amplified inflammatory reactions and was involved in various i...

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Bibliographic Details
Main Authors: Hsin-Ping Pao, Wen-I. Liao, Shih-En Tang, Shu-Yu Wu, Kun-Lun Huang, Shi-Jye Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
4-phenyl butyric acid
hyperoxia
acute lung injury
endoplasmic reticulum stress
claudin-4
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.674316/full

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