Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

Abstract An isocratic RP-HPLC method has been developed for the separation and determination of methocarbamol (MTL), indomethacin (IND), and betamethasone (BET) in combined dosage form using an Inertsil ODS-3v C18 (250 × 4.6 mm, 5 μm) column with UV- detection at 235 nm. Experimental design using Bo...

Full description

Bibliographic Details
Main Authors: Ehab F. Elkady, Marwa A. Fouad, Ayoub N. Mozayad
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Chemistry
Subjects:
Methocarbamol
Indomethacin
Betamethasone
Box-Behnken design
RP-HPLC
Response surface methodology
Online Access:https://doi.org/10.1186/s13065-022-00908-9

Similar Items

Similar Items