Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy)
ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a new surgical technique for patients in whom conventional treatment is not feasible due to insufficient future remnant liver (FRL). During the first stage of ALPPS, accelerated hypertrophy of the FRL is induced b...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2015-11-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | http://www.karger.com/Article/FullText/441385 |
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| author | Kasia P. Cieslak Pim B. Olthof Krijn P. van Lienden Marc G. Besselink Olivier R.C. Busch Thomas M. van Gulik Roelof J. Bennink |
| author_facet | Kasia P. Cieslak Pim B. Olthof Krijn P. van Lienden Marc G. Besselink Olivier R.C. Busch Thomas M. van Gulik Roelof J. Bennink |
| author_sort | Kasia P. Cieslak |
| collection | DOAJ |
| description | ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a new surgical technique for patients in whom conventional treatment is not feasible due to insufficient future remnant liver (FRL). During the first stage of ALPPS, accelerated hypertrophy of the FRL is induced by ligation of the portal vein and in situ split of the liver. In the second stage, the deportalized liver is removed when the FRL volume has reached ≥25% of total liver volume. However, FRL volume does not necessarily reflect FRL function. 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) with SPECT-CT is a quantitative test enabling regional assessment of parenchymal uptake function using a validated cut-off value for the prediction of postoperative liver failure (2.7%/min/m2). This paper describes the changes in FRL function and FRL volume in a 79-year-old patient diagnosed with metachronous colonic liver metastases who underwent ALPPS. We have observed a substantial difference between the increase in FRL volume and FRL function suggesting that HBS with SPECT-CT enables monitoring of the FRL function and could be a useful tool in the timing of resection in the second stage of the ALPPS procedure. |
| first_indexed | 2024-04-13T17:30:14Z |
| format | Article |
| id | doaj.art-13b0bbeb9cfc4d1288f2951c5f256d39 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-13T17:30:14Z |
| publishDate | 2015-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-13b0bbeb9cfc4d1288f2951c5f256d392022-12-22T02:37:36ZengKarger PublishersCase Reports in Gastroenterology1662-06312015-11-019335336010.1159/000441385441385Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy)Kasia P. CieslakPim B. OlthofKrijn P. van LiendenMarc G. BesselinkOlivier R.C. BuschThomas M. van GulikRoelof J. BenninkALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a new surgical technique for patients in whom conventional treatment is not feasible due to insufficient future remnant liver (FRL). During the first stage of ALPPS, accelerated hypertrophy of the FRL is induced by ligation of the portal vein and in situ split of the liver. In the second stage, the deportalized liver is removed when the FRL volume has reached ≥25% of total liver volume. However, FRL volume does not necessarily reflect FRL function. 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) with SPECT-CT is a quantitative test enabling regional assessment of parenchymal uptake function using a validated cut-off value for the prediction of postoperative liver failure (2.7%/min/m2). This paper describes the changes in FRL function and FRL volume in a 79-year-old patient diagnosed with metachronous colonic liver metastases who underwent ALPPS. We have observed a substantial difference between the increase in FRL volume and FRL function suggesting that HBS with SPECT-CT enables monitoring of the FRL function and could be a useful tool in the timing of resection in the second stage of the ALPPS procedure.http://www.karger.com/Article/FullText/441385Postoperative liver failure99mTc-mebrofenin hepatobiliary scintigraphyALPPS (associating liver partition and portal vein ligation for staged hepatectomy)Monitoring of liver function |
| spellingShingle | Kasia P. Cieslak Pim B. Olthof Krijn P. van Lienden Marc G. Besselink Olivier R.C. Busch Thomas M. van Gulik Roelof J. Bennink Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) Case Reports in Gastroenterology Postoperative liver failure 99mTc-mebrofenin hepatobiliary scintigraphy ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) Monitoring of liver function |
| title | Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) |
| title_full | Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) |
| title_fullStr | Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) |
| title_full_unstemmed | Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) |
| title_short | Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) |
| title_sort | assessment of liver function using 99mtc mebrofenin hepatobiliary scintigraphy in alpps associating liver partition and portal vein ligation for staged hepatectomy |
| topic | Postoperative liver failure 99mTc-mebrofenin hepatobiliary scintigraphy ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) Monitoring of liver function |
| url | http://www.karger.com/Article/FullText/441385 |
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