Insights from one thousand cloned dogs
Abstract Animal cloning has been popularized for more than two decades, since the birth of Dolly the Sheep 25 years ago in 1996. There has been an apparent waning of interest in cloning, evident by a reduced number of reports. Over 1500 dogs, representing approximately 20% of the American Kennel Clu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15097-7 |
| _version_ | 1811328307722977280 |
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| author | P. Olof Olsson Yeon Woo Jeong Yeonik Jeong Mina Kang Gang Bae Park Eunji Choi Sun Kim Mohammed Shamim Hossein Young-Bum Son Woo Suk Hwang |
| author_facet | P. Olof Olsson Yeon Woo Jeong Yeonik Jeong Mina Kang Gang Bae Park Eunji Choi Sun Kim Mohammed Shamim Hossein Young-Bum Son Woo Suk Hwang |
| author_sort | P. Olof Olsson |
| collection | DOAJ |
| description | Abstract Animal cloning has been popularized for more than two decades, since the birth of Dolly the Sheep 25 years ago in 1996. There has been an apparent waning of interest in cloning, evident by a reduced number of reports. Over 1500 dogs, representing approximately 20% of the American Kennel Club’s recognized breeds, have now been cloned, making the dog (Canis familiaris) one of the most successfully cloned mammals. Dogs have a unique relationship with humans, dating to prehistory, and a high degree of genome homology to humans. A number of phenotypic variations, rarely recorded in natural reproduction have been observed in in these more than 1000 clones. These observations differ between donors and their clones, and between clones from the same donor, indicating a non-genetic effect. These differences cannot be fully explained by current understandings but point to epigenetic and cellular reprograming effects of somatic cell nuclear transfer. Notably, some phenotypic variations have been reversed through further cloning. Here we summarize these observations and elaborate on the cloning procedure. |
| first_indexed | 2024-04-13T15:24:07Z |
| format | Article |
| id | doaj.art-13b260d744a2472488d549d9b23aea6b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:24:07Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-13b260d744a2472488d549d9b23aea6b2022-12-22T02:41:34ZengNature PortfolioScientific Reports2045-23222022-07-0112111010.1038/s41598-022-15097-7Insights from one thousand cloned dogsP. Olof Olsson0Yeon Woo Jeong1Yeonik Jeong2Mina Kang3Gang Bae Park4Eunji Choi5Sun Kim6Mohammed Shamim Hossein7Young-Bum Son8Woo Suk Hwang9UAE Biotech Research CenterDepartment of Companion Animal and Animal Resources Science, Joongbu UniversityUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterUAE Biotech Research CenterAbstract Animal cloning has been popularized for more than two decades, since the birth of Dolly the Sheep 25 years ago in 1996. There has been an apparent waning of interest in cloning, evident by a reduced number of reports. Over 1500 dogs, representing approximately 20% of the American Kennel Club’s recognized breeds, have now been cloned, making the dog (Canis familiaris) one of the most successfully cloned mammals. Dogs have a unique relationship with humans, dating to prehistory, and a high degree of genome homology to humans. A number of phenotypic variations, rarely recorded in natural reproduction have been observed in in these more than 1000 clones. These observations differ between donors and their clones, and between clones from the same donor, indicating a non-genetic effect. These differences cannot be fully explained by current understandings but point to epigenetic and cellular reprograming effects of somatic cell nuclear transfer. Notably, some phenotypic variations have been reversed through further cloning. Here we summarize these observations and elaborate on the cloning procedure.https://doi.org/10.1038/s41598-022-15097-7 |
| spellingShingle | P. Olof Olsson Yeon Woo Jeong Yeonik Jeong Mina Kang Gang Bae Park Eunji Choi Sun Kim Mohammed Shamim Hossein Young-Bum Son Woo Suk Hwang Insights from one thousand cloned dogs Scientific Reports |
| title | Insights from one thousand cloned dogs |
| title_full | Insights from one thousand cloned dogs |
| title_fullStr | Insights from one thousand cloned dogs |
| title_full_unstemmed | Insights from one thousand cloned dogs |
| title_short | Insights from one thousand cloned dogs |
| title_sort | insights from one thousand cloned dogs |
| url | https://doi.org/10.1038/s41598-022-15097-7 |
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