miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

Abstract Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific mechanism of ototoxicity has not bee...

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Bibliographic Details
Main Authors: Haiyan Wang, Hanqing Lin, Weibiao Kang, Lingfei Huang, Sisi Gong, Tao Zhang, Xiaotong Huang, Feinan He, Yongyi Ye, Yiyang Tang, Haiying Jia, Haidi Yang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Pharmacology and Toxicology
Subjects:
Ototoxicity
miR-34a
DRP-1
Mitophagy
Cisplatin
Online Access:https://doi.org/10.1186/s40360-023-00654-1

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