Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/7/1046 |
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| author | Rafael Moreno-Gómez-Toledano María I. Arenas Esperanza Vélez-Vélez Elisabeth Coll Borja Quiroga Jordi Bover Ricardo J. Bosch |
| author_facet | Rafael Moreno-Gómez-Toledano María I. Arenas Esperanza Vélez-Vélez Elisabeth Coll Borja Quiroga Jordi Bover Ricardo J. Bosch |
| author_sort | Rafael Moreno-Gómez-Toledano |
| collection | DOAJ |
| description | Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health. |
| first_indexed | 2024-03-10T09:44:41Z |
| format | Article |
| id | doaj.art-13b498ac98e04a8ea02baf474bd46649 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T09:44:41Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-13b498ac98e04a8ea02baf474bd466492023-11-22T03:19:23ZengMDPI AGBiomolecules2218-273X2021-07-01117104610.3390/biom11071046Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 StudyRafael Moreno-Gómez-Toledano0María I. Arenas1Esperanza Vélez-Vélez2Elisabeth Coll3Borja Quiroga4Jordi Bover5Ricardo J. Bosch6Universidad de Alcalá, Laboratory of Renal Physiology and Experimental Nephrology, Department of Biological Systems/Physiology, 28871 Alcalá de Henares, SpainUniversidad de Alcalá, Department of Biomedicine and Biotechnology, 28871 Alcalá de Henares, SpainFundación Jiménez Díaz School of Nursing, Jiménez Díaz Foundation, Autonomous University of Madrid, 28040 Madrid, SpainNephrology Service, Fundació Puigvert, 08025 Barcelona, SpainNephrology Service, La Princesa Universitary Hospital, 28806 Madrid, SpainNephrology Service, Germans Trias i Pujol Hospital, Universitat Autònoma de Barcelona, 08916 Badalona, SpainUniversidad de Alcalá, Laboratory of Renal Physiology and Experimental Nephrology, Department of Biological Systems/Physiology, 28871 Alcalá de Henares, SpainBisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health.https://www.mdpi.com/2218-273X/11/7/1046bisphenol Akidneysystematic reviewmeta-analysis |
| spellingShingle | Rafael Moreno-Gómez-Toledano María I. Arenas Esperanza Vélez-Vélez Elisabeth Coll Borja Quiroga Jordi Bover Ricardo J. Bosch Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study Biomolecules bisphenol A kidney systematic review meta-analysis |
| title | Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study |
| title_full | Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study |
| title_fullStr | Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study |
| title_full_unstemmed | Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study |
| title_short | Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study |
| title_sort | bisphenol a exposure and kidney diseases systematic review meta analysis and nhanes 03 16 study |
| topic | bisphenol A kidney systematic review meta-analysis |
| url | https://www.mdpi.com/2218-273X/11/7/1046 |
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