Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature
Objective and Importance: Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported.1-11 We report a case o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00130/full |
| _version_ | 1828353986305982464 |
|---|---|
| author | Naveen ePemmaraju Elaine eChang Naval eDaver Keyur ePatel Jeffrey eJorgensen Bradley eSabloff Srdan eVerstovsek Gautam eBorthakur |
| author_facet | Naveen ePemmaraju Elaine eChang Naval eDaver Keyur ePatel Jeffrey eJorgensen Bradley eSabloff Srdan eVerstovsek Gautam eBorthakur |
| author_sort | Naveen ePemmaraju |
| collection | DOAJ |
| description | Objective and Importance: Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature. Clinical presentation: In this case, a 55 year old man with previous history of myeloproliferative neoplasm (MPN) experienced transformation AML, heralded by appearance of leukemic pleural effusions. The patient was identified to have leukemic pleural effusion based upon extended cytogenetic analysis of the pleural fluid, as morphologic analysis alone was insufficient. Intervention: The patient was treated with hypomethylator-based and intensive chemotherapy strategies, both of which maintained resolution of the effusions in the remission setting. Conclusion: Due to the rarity of diagnosis of leukemic pleural effusions, both cytogenetic and fluorescence in situ hybridization (FISH) testing are recommended. Futhermore, systemic chemotherapy directed at the AML can lead to complete resolution of leukemic pleural effusions. <br/><br/>Objective and Importance<br/>Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML), but may be more common than previously thought. Fewer than 20 cases have been reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature.<br/> |
| first_indexed | 2024-04-14T02:16:06Z |
| format | Article |
| id | doaj.art-13b4aca5f4f844f1b56f21c9d1b78e4e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T02:16:06Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-13b4aca5f4f844f1b56f21c9d1b78e4e2022-12-22T02:18:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-06-01410.3389/fonc.2014.0013092013Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the LiteratureNaveen ePemmaraju0Elaine eChang1Naval eDaver2Keyur ePatel3Jeffrey eJorgensen4Bradley eSabloff5Srdan eVerstovsek6Gautam eBorthakur7MD AndersonMD AndersonMD AndersonMD AndersonMD AndersonMD AndersonMD AndersonMD AndersonObjective and Importance: Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature. Clinical presentation: In this case, a 55 year old man with previous history of myeloproliferative neoplasm (MPN) experienced transformation AML, heralded by appearance of leukemic pleural effusions. The patient was identified to have leukemic pleural effusion based upon extended cytogenetic analysis of the pleural fluid, as morphologic analysis alone was insufficient. Intervention: The patient was treated with hypomethylator-based and intensive chemotherapy strategies, both of which maintained resolution of the effusions in the remission setting. Conclusion: Due to the rarity of diagnosis of leukemic pleural effusions, both cytogenetic and fluorescence in situ hybridization (FISH) testing are recommended. Futhermore, systemic chemotherapy directed at the AML can lead to complete resolution of leukemic pleural effusions. <br/><br/>Objective and Importance<br/>Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML), but may be more common than previously thought. Fewer than 20 cases have been reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature.<br/>http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00130/fullAcute Myeloid LeukemiamalignantExtramedullary AMLpleuraleffusion |
| spellingShingle | Naveen ePemmaraju Elaine eChang Naval eDaver Keyur ePatel Jeffrey eJorgensen Bradley eSabloff Srdan eVerstovsek Gautam eBorthakur Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature Frontiers in Oncology Acute Myeloid Leukemia malignant Extramedullary AML pleural effusion |
| title | Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature |
| title_full | Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature |
| title_fullStr | Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature |
| title_full_unstemmed | Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature |
| title_short | Extramedullary Acute Myeloid Leukemia (AML): Leukemic Pleural Effusion, Case Report and Review of the Literature |
| title_sort | extramedullary acute myeloid leukemia aml leukemic pleural effusion case report and review of the literature |
| topic | Acute Myeloid Leukemia malignant Extramedullary AML pleural effusion |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00130/full |
| work_keys_str_mv | AT naveenepemmaraju extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT elaineechang extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT navaledaver extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT keyurepatel extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT jeffreyejorgensen extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT bradleyesabloff extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT srdaneverstovsek extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature AT gautameborthakur extramedullaryacutemyeloidleukemiaamlleukemicpleuraleffusioncasereportandreviewoftheliterature |