Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation

Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation

Voriconazole (VCZ) is a well-known broad spectrum triazole antifungal, mainly used orally and intravenously. The study aimed to formulate VCZ into ultradeformable elastosomes for the topical treatment of ocular fungal keratitis. Different formulae were prepared using a modified ethanol injection met...

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Bibliographic Details
Main Authors: Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel, Abdulaziz Mohsen Al-Mahallawi
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
voriconazole
modified ethanol injection method
hyaluronic acid
brij s100 ocular safety
antifungal susceptibility testing
Online Access:http://dx.doi.org/10.1080/10717544.2020.1858997

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