Subunit gating resulting from individual protonation events in Kir2 channels

Subunit gating resulting from individual protonation events in Kir2 channels

Abstract Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore. Introduced negative charges at the HBC (G178D) in Kir2.2 channels forces opening, allowing pore wetting and free movement of per...

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Bibliographic Details
Main Authors:	Grigory Maksaev, Michael Bründl-Jirout, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Colin G. Nichols
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-40058-7

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