Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma

Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma

Abstract Background Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our previous study revealed that glucose metabolism may play an important role in the pathogenesis of IH and that the inhibition of the glycolytic key enzyme pho...

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Bibliographic Details
Main Authors: Kaiying Yang, Tong Qiu, Jiangyuan Zhou, Xue Gong, Xuepeng Zhang, Yuru Lan, Zixin Zhang, Yi Ji
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
Infantile hemangioma
Glycolysis
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Angiogenesis
Online Access:https://doi.org/10.1186/s12967-023-03932-y

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