Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants
Abstract Background This study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages. Methods Our retrospective study involved 282 infants under the age of 120 days wit...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-020-02172-z |
| _version_ | 1819162828258410496 |
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| author | Qiulong Shen Sarah Siyin Tan Zengmeng Wang Siyu Cai Wenbo Pang Chunhui Peng Yajun Chen |
| author_facet | Qiulong Shen Sarah Siyin Tan Zengmeng Wang Siyu Cai Wenbo Pang Chunhui Peng Yajun Chen |
| author_sort | Qiulong Shen |
| collection | DOAJ |
| description | Abstract Background This study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages. Methods Our retrospective study involved 282 infants under the age of 120 days with jaundice who were admitted into Beijing Children’s Hospital between January 2016 to December 2018. The GGT and LSM levels of infants were obtained. A parallel test was used, and ROC curve was created to obtain cutoff values of GGT and LSM for BA infants at different ages. Results Of the 282 infants, 135 were diagnosed with BA and 147 were non-BA infants. In all age groups (A: ≤60 days; B: 61–90 days; C: 91–120 days), the LSM and GGT levels of the BA group were significantly higher than that of the non-BA group, P < 0.05. The cutoff value of GGT and LSM to diagnosis BA was 191.2 U/L, 213.2 U/L, 281.5 U/L and 7.5 kPa, 10.0 kPa, 11.0 kPa in groups A, B and C, respectively. The parallel test was used to determine a sensitivity of 97.3, 98.1 and 100% in group A, B and C when either GGT or LSM levels were met in BA infants. The sensitivities of parallel testing for group A and B were higher than LSM or GGT used alone. Conclusions Cutoff values of GGT and LSM to screen BA increased with age. Parallel testing of GGT and LSM in infants who are younger than 90 days old can decrease the rate of BA misdiagnosis. |
| first_indexed | 2024-12-22T17:34:26Z |
| format | Article |
| id | doaj.art-13b8c350efc0401aa6d12946d9a7dd35 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-22T17:34:26Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-13b8c350efc0401aa6d12946d9a7dd352022-12-21T18:18:32ZengBMCBMC Pediatrics1471-24312020-06-012011810.1186/s12887-020-02172-zCombination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infantsQiulong Shen0Sarah Siyin Tan1Zengmeng Wang2Siyu Cai3Wenbo Pang4Chunhui Peng5Yajun Chen6Department of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthDepartment of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthDepartment of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthDepartment of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthDepartment of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthDepartment of General Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthAbstract Background This study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages. Methods Our retrospective study involved 282 infants under the age of 120 days with jaundice who were admitted into Beijing Children’s Hospital between January 2016 to December 2018. The GGT and LSM levels of infants were obtained. A parallel test was used, and ROC curve was created to obtain cutoff values of GGT and LSM for BA infants at different ages. Results Of the 282 infants, 135 were diagnosed with BA and 147 were non-BA infants. In all age groups (A: ≤60 days; B: 61–90 days; C: 91–120 days), the LSM and GGT levels of the BA group were significantly higher than that of the non-BA group, P < 0.05. The cutoff value of GGT and LSM to diagnosis BA was 191.2 U/L, 213.2 U/L, 281.5 U/L and 7.5 kPa, 10.0 kPa, 11.0 kPa in groups A, B and C, respectively. The parallel test was used to determine a sensitivity of 97.3, 98.1 and 100% in group A, B and C when either GGT or LSM levels were met in BA infants. The sensitivities of parallel testing for group A and B were higher than LSM or GGT used alone. Conclusions Cutoff values of GGT and LSM to screen BA increased with age. Parallel testing of GGT and LSM in infants who are younger than 90 days old can decrease the rate of BA misdiagnosis.http://link.springer.com/article/10.1186/s12887-020-02172-zBiliary atresiaInfantile cholestatic jaundiceMisdiagnosisParallel test |
| spellingShingle | Qiulong Shen Sarah Siyin Tan Zengmeng Wang Siyu Cai Wenbo Pang Chunhui Peng Yajun Chen Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants BMC Pediatrics Biliary atresia Infantile cholestatic jaundice Misdiagnosis Parallel test |
| title | Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants |
| title_full | Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants |
| title_fullStr | Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants |
| title_full_unstemmed | Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants |
| title_short | Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants |
| title_sort | combination of gamma glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages a retrospective analysis of 282 infants |
| topic | Biliary atresia Infantile cholestatic jaundice Misdiagnosis Parallel test |
| url | http://link.springer.com/article/10.1186/s12887-020-02172-z |
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