PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease
Fatty liver disease (FLD) affects more than one-third of the population in the western world and an increasing number of children in the United States. It is a leading cause of obesity and liver transplantation. Mechanistic insights into the causes of FLD are urgently needed since no therapeutic int...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Adipocyte |
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| Online Access: | http://dx.doi.org/10.1080/21623945.2019.1607423 |
| _version_ | 1819105673979363328 |
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| author | Soumik Basu Ray |
| author_facet | Soumik Basu Ray |
| author_sort | Soumik Basu Ray |
| collection | DOAJ |
| description | Fatty liver disease (FLD) affects more than one-third of the population in the western world and an increasing number of children in the United States. It is a leading cause of obesity and liver transplantation. Mechanistic insights into the causes of FLD are urgently needed since no therapeutic intervention has proven to be effective. A sequence variation in patatin like phospholipase domain-containing protein 3 (PNPLA3), rs 738409, is strongly associated with the progression of fatty liver disease. The resulting mutant causes a substitution of isoleucine to methionine at position 148. The underlying mechanism of this disease remains unsolved although several studies have illuminated key insights into its pathogenesis. This review highlights the progress in our understanding of PNPLA3 function in lipid droplet dynamics and explores possible therapeutic interventions to ameliorate this human health hazard. |
| first_indexed | 2024-12-22T02:26:00Z |
| format | Article |
| id | doaj.art-13b8f8effba740c29a0103583c4daf1e |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-12-22T02:26:00Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-13b8f8effba740c29a0103583c4daf1e2022-12-21T18:42:01ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2019-01-018120120810.1080/21623945.2019.16074231607423PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver diseaseSoumik Basu Ray0University of Texas Southwestern Medical CenterFatty liver disease (FLD) affects more than one-third of the population in the western world and an increasing number of children in the United States. It is a leading cause of obesity and liver transplantation. Mechanistic insights into the causes of FLD are urgently needed since no therapeutic intervention has proven to be effective. A sequence variation in patatin like phospholipase domain-containing protein 3 (PNPLA3), rs 738409, is strongly associated with the progression of fatty liver disease. The resulting mutant causes a substitution of isoleucine to methionine at position 148. The underlying mechanism of this disease remains unsolved although several studies have illuminated key insights into its pathogenesis. This review highlights the progress in our understanding of PNPLA3 function in lipid droplet dynamics and explores possible therapeutic interventions to ameliorate this human health hazard.http://dx.doi.org/10.1080/21623945.2019.1607423fatty liver diseaselipid dropletpnpla3proteasomeautophagy |
| spellingShingle | Soumik Basu Ray PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease Adipocyte fatty liver disease lipid droplet pnpla3 proteasome autophagy |
| title | PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease |
| title_full | PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease |
| title_fullStr | PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease |
| title_full_unstemmed | PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease |
| title_short | PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease |
| title_sort | pnpla3 i148m a problem of plenty in non alcoholic fatty liver disease |
| topic | fatty liver disease lipid droplet pnpla3 proteasome autophagy |
| url | http://dx.doi.org/10.1080/21623945.2019.1607423 |
| work_keys_str_mv | AT soumikbasuray pnpla3i148maproblemofplentyinnonalcoholicfattyliverdisease |