Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy
The human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body, including the mouth, lung, intestines, skin, and vagina. These microbial communities are involved in many essential functions, such as metabolis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2022-01-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1886 |
| _version_ | 1818974428016410624 |
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| author | Jiali Dong Yuan Li Huiwen Xiao Ming Cui Saijun Fan |
| author_facet | Jiali Dong Yuan Li Huiwen Xiao Ming Cui Saijun Fan |
| author_sort | Jiali Dong |
| collection | DOAJ |
| description | The human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body, including the mouth, lung, intestines, skin, and vagina. These microbial communities are involved in many essential functions, such as metabolism, immunity, host nutrition, and diseases. Recent studies have focused on the microbiota associated with cancers, particularly the oral and intestinal microbiota. Radiotherapy, the most effective cytotoxic modality available for solid tumors, contributes to the treatment of cancer patients. Mounting evidence supports that the microbiota plays pivotal roles in the efficacy and prognosis of tumor radiotherapy. Here, we review current research on the microbiota and cancer development, and describe knowledge gaps in the study of radiotherapy and the microbiota. Better understanding of the effects of the microbiome in tumorigenesis and radiotherapy will shed light on future novel prevention and treatment strategies based on modulating the microbiome in cancer patients. |
| first_indexed | 2024-12-20T15:39:54Z |
| format | Article |
| id | doaj.art-13ba753388344a27b73dacde2b81580e |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-12-20T15:39:54Z |
| publishDate | 2022-01-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-13ba753388344a27b73dacde2b81580e2022-12-21T19:35:13ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412022-01-01191435510.20892/j.issn.2095-3941.2020.0476Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapyJiali Dong0Yuan Li1Huiwen Xiao2Ming Cui3Saijun Fan4Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, ChinaDepartment of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, ChinaThe human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body, including the mouth, lung, intestines, skin, and vagina. These microbial communities are involved in many essential functions, such as metabolism, immunity, host nutrition, and diseases. Recent studies have focused on the microbiota associated with cancers, particularly the oral and intestinal microbiota. Radiotherapy, the most effective cytotoxic modality available for solid tumors, contributes to the treatment of cancer patients. Mounting evidence supports that the microbiota plays pivotal roles in the efficacy and prognosis of tumor radiotherapy. Here, we review current research on the microbiota and cancer development, and describe knowledge gaps in the study of radiotherapy and the microbiota. Better understanding of the effects of the microbiome in tumorigenesis and radiotherapy will shed light on future novel prevention and treatment strategies based on modulating the microbiome in cancer patients.http://www.cancerbiomed.org/index.php/cocr/article/view/1886oral microbiomegut microbiomecancerradiotherapy |
| spellingShingle | Jiali Dong Yuan Li Huiwen Xiao Ming Cui Saijun Fan Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy Cancer Biology & Medicine oral microbiome gut microbiome cancer radiotherapy |
| title | Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy |
| title_full | Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy |
| title_fullStr | Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy |
| title_full_unstemmed | Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy |
| title_short | Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy |
| title_sort | commensal microbiota in the digestive tract a review of its roles in carcinogenesis and radiotherapy |
| topic | oral microbiome gut microbiome cancer radiotherapy |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1886 |
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