The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring
The incidence of obesity in women of reproductive age has significantly increased over the past 100 years. There is a well-established connection between maternal obesity during pregnancy and an increased risk of developing non-communicable cardiometabolic diseases in her offspring. This mini-review...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.730037/full |
| _version_ | 1819144590257553408 |
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| author | Emma J. Buckels Scott M. Bolam Scott M. Bolam Mei Lin Tay Brya G. Matthews |
| author_facet | Emma J. Buckels Scott M. Bolam Scott M. Bolam Mei Lin Tay Brya G. Matthews |
| author_sort | Emma J. Buckels |
| collection | DOAJ |
| description | The incidence of obesity in women of reproductive age has significantly increased over the past 100 years. There is a well-established connection between maternal obesity during pregnancy and an increased risk of developing non-communicable cardiometabolic diseases in her offspring. This mini-review focuses on evidence examining the effect of maternal high-fat diet (HFD) on skeletal development and bone health in later life in offspring. The majority of rodent studies indicate that maternal HFD generally negatively affects both embryonic bone development and bone volume in adult animals. Details surrounding the mechanisms of action that drive changes in the skeleton in offspring remain unclear, although numerous studies suggest that some effects are sex-specific. Human studies in this area are limited but also suggest that HFD during pregnancy may impair bone formation and increase fracture risk during childhood. Given the consequences of low bone mass and deranged bone microarchitecture for offspring, advances in our understanding of the developmental origins of bone health is critical in the battle against osteoporosis. |
| first_indexed | 2024-12-22T12:44:33Z |
| format | Article |
| id | doaj.art-13ba7c8342934cfcb498f8c9d2d54419 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-22T12:44:33Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-13ba7c8342934cfcb498f8c9d2d544192022-12-21T18:25:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-08-01810.3389/fnut.2021.730037730037The Impact of Maternal High-Fat Diet on Bone Microarchitecture in OffspringEmma J. Buckels0Scott M. Bolam1Scott M. Bolam2Mei Lin Tay3Brya G. Matthews4Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New ZealandDepartment of Surgery, School of Medicine, University of Auckland, Auckland, New ZealandDepartment of Orthopaedic Surgery, Auckland City Hospital, Auckland, New ZealandDepartment of Surgery, School of Medicine, University of Auckland, Auckland, New ZealandDepartment of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New ZealandThe incidence of obesity in women of reproductive age has significantly increased over the past 100 years. There is a well-established connection between maternal obesity during pregnancy and an increased risk of developing non-communicable cardiometabolic diseases in her offspring. This mini-review focuses on evidence examining the effect of maternal high-fat diet (HFD) on skeletal development and bone health in later life in offspring. The majority of rodent studies indicate that maternal HFD generally negatively affects both embryonic bone development and bone volume in adult animals. Details surrounding the mechanisms of action that drive changes in the skeleton in offspring remain unclear, although numerous studies suggest that some effects are sex-specific. Human studies in this area are limited but also suggest that HFD during pregnancy may impair bone formation and increase fracture risk during childhood. Given the consequences of low bone mass and deranged bone microarchitecture for offspring, advances in our understanding of the developmental origins of bone health is critical in the battle against osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2021.730037/fullearly life nutritionmaternal obesitydevelopmental origins of health and disease (DOHaD)osteoporosisosteoblastosteoclast |
| spellingShingle | Emma J. Buckels Scott M. Bolam Scott M. Bolam Mei Lin Tay Brya G. Matthews The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring Frontiers in Nutrition early life nutrition maternal obesity developmental origins of health and disease (DOHaD) osteoporosis osteoblast osteoclast |
| title | The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring |
| title_full | The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring |
| title_fullStr | The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring |
| title_full_unstemmed | The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring |
| title_short | The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring |
| title_sort | impact of maternal high fat diet on bone microarchitecture in offspring |
| topic | early life nutrition maternal obesity developmental origins of health and disease (DOHaD) osteoporosis osteoblast osteoclast |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.730037/full |
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