Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant
Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund’s complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2015-07-01
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| Series: | Acta Medica |
| Subjects: |
| _version_ | 1828836153766182912 |
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| author | Miroslav Pohanka Branislav Ruttkay-Nedecký Josef Fusek Vojtěch Adam René Kizek |
| author_facet | Miroslav Pohanka Branislav Ruttkay-Nedecký Josef Fusek Vojtěch Adam René Kizek |
| author_sort | Miroslav Pohanka |
| collection | DOAJ |
| description | Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund’s complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis. |
| first_indexed | 2024-12-12T18:16:53Z |
| format | Article |
| id | doaj.art-13ba96b5ce154ebd89e687334c8248fd |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-12T18:16:53Z |
| publishDate | 2015-07-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-13ba96b5ce154ebd89e687334c8248fd2022-12-22T00:16:14ZengKarolinum PressActa Medica1211-42861805-96942015-07-01581212410.14712/18059694.2015.872764Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete AdjuvantMiroslav PohankaBranislav Ruttkay-NedeckýJosef FusekVojtěch AdamRené KizekMelatonin is a hormone with strong antioxidant properties. In this experiment, Freund’s complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis.AntioxidantOxidative stressMelatoninReactive oxygen speciesEpiphysisHormone |
| spellingShingle | Miroslav Pohanka Branislav Ruttkay-Nedecký Josef Fusek Vojtěch Adam René Kizek Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant Acta Medica Antioxidant Oxidative stress Melatonin Reactive oxygen species Epiphysis Hormone |
| title | Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant |
| title_full | Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant |
| title_fullStr | Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant |
| title_full_unstemmed | Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant |
| title_short | Melatonin Regulates Oxidative Stress Initiated by Freund’s Complete Adjuvant |
| title_sort | melatonin regulates oxidative stress initiated by freund s complete adjuvant |
| topic | Antioxidant Oxidative stress Melatonin Reactive oxygen species Epiphysis Hormone |
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