Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion

Introduction Acute ischemic stroke (AIS) from arterial occlusions are treated with emergent endovascular thrombectomy (EVT) when clinically appropriate. Clinical outcomes of EVT in medium vessel occlusion (MVO) compared to large vessel occlusion (LVO) have neither been well established nor compared...

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Main Authors: Farah Y Fourcand, Sean Scarpiello, Abdallah Amireh, Thomas Snyder, Shrinjay Vyas, Rudra Joshi, Ilya Dubinsky, Brigitte Percival, Haralabos Zacharatos, Siddhart Mehta, Jawad F Kirmani
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Stroke: Vascular and Interventional Neurology
Online Access:https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.LBA7
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author Farah Y Fourcand
Sean Scarpiello
Abdallah Amireh
Thomas Snyder
Shrinjay Vyas
Rudra Joshi
Ilya Dubinsky
Brigitte Percival
Haralabos Zacharatos
Siddhart Mehta
Jawad F Kirmani
author_facet Farah Y Fourcand
Sean Scarpiello
Abdallah Amireh
Thomas Snyder
Shrinjay Vyas
Rudra Joshi
Ilya Dubinsky
Brigitte Percival
Haralabos Zacharatos
Siddhart Mehta
Jawad F Kirmani
author_sort Farah Y Fourcand
collection DOAJ
description Introduction Acute ischemic stroke (AIS) from arterial occlusions are treated with emergent endovascular thrombectomy (EVT) when clinically appropriate. Clinical outcomes of EVT in medium vessel occlusion (MVO) compared to large vessel occlusion (LVO) have neither been well established nor compared to alternate medical management. Our aim was to evaluate outcomes of patients with AIS secondary to MVO undergoing EVT. Methods We conducted a retrospective chart review of patients presenting to our comprehensive stroke center with MVO‐associated AIS undergoing EVT or aggressive intra‐arterial thrombolytic treatment with concurrent administration of IV eptifibatide. We assessed occlusion site, NIHSS (presentation, 7 day or discharge, 3 months), modified Rankin Scale (baseline, 90‐day), and intracranial hemorrhage (ICH) rate. MVO was defined as occlusion of pure M2 middle cerebral artery without M1 segment involvement, anterior cerebral artery A1 segment or more distal, and posterior cerebral artery P1 segment or more distal. Mann‐Whitney U test, Fisher exact test statistic, and T‐test statistic were used for analysis. Social science statistics software was used for data analysis. Results From August 2020 to December 2021, out of 175 patients who underwent EVT, 50 had MVO (n = 33 M2 occlusion, n = 12 M3 occlusion, n = 1 for P1, P2, A1, A2, A3 each). Twelve subjects with MVO received aggressive medical management with concurrent IV eptifibatide. Subjects between arms were similar at baseline (median NIHSS 11 [95% CI 10.75, 14.32]; mean age 71.5 [95% CI 69.24, 73.77]; male 48.39% [n = 30]). The difference between initial NIHSS and discharge NIHSS was statistically significant in the EVT arm (Z‐Score = 4.03; p‐value < .00001) but not in the medical arm (Z‐score = 1.96; p‐value 0.05). Hemorrhagic transformation occurred in 28% (n = 14) of EVT arm and 16.67% (n = 2) of medical arm. This was not statistically significant (Fisher value: 0.71). Median 90 day mRS was 1 (95% CI [0.89, 2.11]). The difference between 90 day mRS was not significantly different (Z‐score = ‐1.20; p‐value 0.23). Conclusions In our patient cohort, endovascular therapy was safe in medium vessel occlusion and may have more favorable clinical outcomes as illustrated by higher delta NIHSS in the endovascular thrombectomy group. Larger, prospective studies are needed to validate our results.
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spelling doaj.art-13bacfe428674fc69c12168e71c23ba22023-06-15T10:40:49ZengWileyStroke: Vascular and Interventional Neurology2694-57462023-03-013S110.1161/SVIN.03.suppl_1.LBA7Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel OcclusionFarah Y Fourcand0Sean Scarpiello1Abdallah Amireh2Thomas Snyder3Shrinjay Vyas4Rudra Joshi5Ilya Dubinsky6Brigitte Percival7Haralabos Zacharatos8Siddhart Mehta9Jawad F Kirmani10Hackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaHackensack Meridian JFK University Medical Center Edison New Jersey United States of AmericaIntroduction Acute ischemic stroke (AIS) from arterial occlusions are treated with emergent endovascular thrombectomy (EVT) when clinically appropriate. Clinical outcomes of EVT in medium vessel occlusion (MVO) compared to large vessel occlusion (LVO) have neither been well established nor compared to alternate medical management. Our aim was to evaluate outcomes of patients with AIS secondary to MVO undergoing EVT. Methods We conducted a retrospective chart review of patients presenting to our comprehensive stroke center with MVO‐associated AIS undergoing EVT or aggressive intra‐arterial thrombolytic treatment with concurrent administration of IV eptifibatide. We assessed occlusion site, NIHSS (presentation, 7 day or discharge, 3 months), modified Rankin Scale (baseline, 90‐day), and intracranial hemorrhage (ICH) rate. MVO was defined as occlusion of pure M2 middle cerebral artery without M1 segment involvement, anterior cerebral artery A1 segment or more distal, and posterior cerebral artery P1 segment or more distal. Mann‐Whitney U test, Fisher exact test statistic, and T‐test statistic were used for analysis. Social science statistics software was used for data analysis. Results From August 2020 to December 2021, out of 175 patients who underwent EVT, 50 had MVO (n = 33 M2 occlusion, n = 12 M3 occlusion, n = 1 for P1, P2, A1, A2, A3 each). Twelve subjects with MVO received aggressive medical management with concurrent IV eptifibatide. Subjects between arms were similar at baseline (median NIHSS 11 [95% CI 10.75, 14.32]; mean age 71.5 [95% CI 69.24, 73.77]; male 48.39% [n = 30]). The difference between initial NIHSS and discharge NIHSS was statistically significant in the EVT arm (Z‐Score = 4.03; p‐value < .00001) but not in the medical arm (Z‐score = 1.96; p‐value 0.05). Hemorrhagic transformation occurred in 28% (n = 14) of EVT arm and 16.67% (n = 2) of medical arm. This was not statistically significant (Fisher value: 0.71). Median 90 day mRS was 1 (95% CI [0.89, 2.11]). The difference between 90 day mRS was not significantly different (Z‐score = ‐1.20; p‐value 0.23). Conclusions In our patient cohort, endovascular therapy was safe in medium vessel occlusion and may have more favorable clinical outcomes as illustrated by higher delta NIHSS in the endovascular thrombectomy group. Larger, prospective studies are needed to validate our results.https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.LBA7
spellingShingle Farah Y Fourcand
Sean Scarpiello
Abdallah Amireh
Thomas Snyder
Shrinjay Vyas
Rudra Joshi
Ilya Dubinsky
Brigitte Percival
Haralabos Zacharatos
Siddhart Mehta
Jawad F Kirmani
Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
Stroke: Vascular and Interventional Neurology
title Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
title_full Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
title_fullStr Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
title_full_unstemmed Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
title_short Abstract Number: LBA7 Outcomes of Endovascular Thrombectomy Versus Medical Treatment in Ischemic Strokes Secondary to Medium Vessel Occlusion
title_sort abstract number lba7 outcomes of endovascular thrombectomy versus medical treatment in ischemic strokes secondary to medium vessel occlusion
url https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.LBA7
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