Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad
Tsetse flies (genus Glossina) transmit deadly trypanosomes to human populations and domestic animals in sub-Saharan Africa. Some foci of Human African Trypanosomiasis due to Trypanosoma brucei gambiense (g-HAT) persist in southern Chad, where a program of tsetse control was implemented against the l...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | Parasite |
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| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2024/01/parasite230149/parasite230149.html |
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| author | Ravel Sophie Ségard Adeline Mollo Brahim Guihini Mahamat Mahamat Hissène Argiles-Herrero Rafael Bouyer Jérémy Rayaisse Jean-Baptiste Solano Philippe Pèka Mallaye Darnas Justin Belem Adrien Marie Gaston Yoni Wilfrid Noûs Camille de Meeûs Thierry |
| author_facet | Ravel Sophie Ségard Adeline Mollo Brahim Guihini Mahamat Mahamat Hissène Argiles-Herrero Rafael Bouyer Jérémy Rayaisse Jean-Baptiste Solano Philippe Pèka Mallaye Darnas Justin Belem Adrien Marie Gaston Yoni Wilfrid Noûs Camille de Meeûs Thierry |
| author_sort | Ravel Sophie |
| collection | DOAJ |
| description | Tsetse flies (genus Glossina) transmit deadly trypanosomes to human populations and domestic animals in sub-Saharan Africa. Some foci of Human African Trypanosomiasis due to Trypanosoma brucei gambiense (g-HAT) persist in southern Chad, where a program of tsetse control was implemented against the local vector Glossina fuscipes fuscipes in 2018 in Maro. We analyzed the population genetics of G. f. fuscipes from the Maro focus before control (T0), one year (T1), and 18 months (T2) after the beginning of control efforts. Most flies captured displayed a local genetic profile (local survivors), but a few flies displayed outlier genotypes. Moreover, disturbance of isolation by distance signature (increase of genetic distance with geographic distance) and effective population size estimates, absence of any genetic signature of a bottleneck, and an increase of genetic diversity between T0 and T2 strongly suggest gene flows from various origins, and a limited impact of the vector control efforts on this tsetse population. Continuous control and surveillance of g-HAT transmission is thus recommended in Maro. Particular attention will need to be paid to the border with the Central African Republic, a country where the entomological and epidemiological status of g-HAT is unknown. |
| first_indexed | 2024-04-25T01:38:34Z |
| format | Article |
| id | doaj.art-13bd9bbcf319491082c18cf01cf53d77 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-04-25T01:38:34Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-13bd9bbcf319491082c18cf01cf53d772024-03-08T07:51:32ZengEDP SciencesParasite1776-10422024-01-01311310.1051/parasite/2024013parasite230149Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, ChadRavel Sophie0https://orcid.org/0000-0002-3093-5208Ségard Adeline1https://orcid.org/0000-0002-3826-3194Mollo Brahim Guihini2Mahamat Mahamat Hissène3Argiles-Herrero Rafael4https://orcid.org/0000-0003-0812-0595Bouyer Jérémy5https://orcid.org/0000-0002-1913-416XRayaisse Jean-Baptiste6https://orcid.org/0000-0001-9642-4702Solano Philippe7https://orcid.org/0000-0002-4351-3506Pèka Mallaye8Darnas Justin9Belem Adrien Marie Gaston10https://orcid.org/0000-0001-7405-1626Yoni Wilfrid11https://orcid.org/0000-0002-1156-8350Noûs Camille12de Meeûs Thierry13https://orcid.org/0000-0001-8807-241XIntertryp, Université de Montpellier, Cirad, IRDIntertryp, Université de Montpellier, Cirad, IRDInstitut de Recherche en Élevage pour le Développement (IRED)Institut de Recherche en Élevage pour le Développement (IRED)Insect Pest Control Laboratory, Joint Food and Agriculture Organization of the United Nations/International Atomic Energy Agency Program of Nuclear Techniques in Food and AgricultureInsect Pest Control Laboratory, Joint Food and Agriculture Organization of the United Nations/International Atomic Energy Agency Program of Nuclear Techniques in Food and AgricultureCentre International de Recherche Développement sur l’Élevage en zone Subhumide (Cirdes)Intertryp, Université de Montpellier, Cirad, IRDProgramme National de Lutte contre la THA (PNLTHA)Programme National de Lutte contre la THA (PNLTHA)Université Nazi BoniCentre International de Recherche Développement sur l’Élevage en zone Subhumide (Cirdes)Cogitamus LaboratoryIntertryp, Université de Montpellier, Cirad, IRDTsetse flies (genus Glossina) transmit deadly trypanosomes to human populations and domestic animals in sub-Saharan Africa. Some foci of Human African Trypanosomiasis due to Trypanosoma brucei gambiense (g-HAT) persist in southern Chad, where a program of tsetse control was implemented against the local vector Glossina fuscipes fuscipes in 2018 in Maro. We analyzed the population genetics of G. f. fuscipes from the Maro focus before control (T0), one year (T1), and 18 months (T2) after the beginning of control efforts. Most flies captured displayed a local genetic profile (local survivors), but a few flies displayed outlier genotypes. Moreover, disturbance of isolation by distance signature (increase of genetic distance with geographic distance) and effective population size estimates, absence of any genetic signature of a bottleneck, and an increase of genetic diversity between T0 and T2 strongly suggest gene flows from various origins, and a limited impact of the vector control efforts on this tsetse population. Continuous control and surveillance of g-HAT transmission is thus recommended in Maro. Particular attention will need to be paid to the border with the Central African Republic, a country where the entomological and epidemiological status of g-HAT is unknown.https://www.parasite-journal.org/articles/parasite/full_html/2024/01/parasite230149/parasite230149.htmltsetse fliesdispersaltrypanosomosiscontrol |
| spellingShingle | Ravel Sophie Ségard Adeline Mollo Brahim Guihini Mahamat Mahamat Hissène Argiles-Herrero Rafael Bouyer Jérémy Rayaisse Jean-Baptiste Solano Philippe Pèka Mallaye Darnas Justin Belem Adrien Marie Gaston Yoni Wilfrid Noûs Camille de Meeûs Thierry Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad Parasite tsetse flies dispersal trypanosomosis control |
| title | Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad |
| title_full | Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad |
| title_fullStr | Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad |
| title_full_unstemmed | Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad |
| title_short | Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad |
| title_sort | limited impact of vector control on the population genetic structure of glossina fuscipes fuscipes from the sleeping sickness focus of maro chad |
| topic | tsetse flies dispersal trypanosomosis control |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2024/01/parasite230149/parasite230149.html |
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