Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy
Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916915/full |
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| author | Zi-Yue Zhao Zi-Yue Zhao Zhuo-Yuan Chen Zhuo-Yuan Chen Bin Yu Bin Yu Bo Xiao Bo Xiao Li-Yan Liu Li-Yan Liu Yu Xia Yu Xia Ao-Yu Li Ao-Yu Li Ping-Xiao Wang Ping-Xiao Wang Cheng Xiang Cheng Xiang Chao Liu Chao Liu Hui-Qin Yang Hui-Qin Yang Hui-Qin Yang Hui Li Hui Li Tao Xiao Tao Xiao |
| author_facet | Zi-Yue Zhao Zi-Yue Zhao Zhuo-Yuan Chen Zhuo-Yuan Chen Bin Yu Bin Yu Bo Xiao Bo Xiao Li-Yan Liu Li-Yan Liu Yu Xia Yu Xia Ao-Yu Li Ao-Yu Li Ping-Xiao Wang Ping-Xiao Wang Cheng Xiang Cheng Xiang Chao Liu Chao Liu Hui-Qin Yang Hui-Qin Yang Hui-Qin Yang Hui Li Hui Li Tao Xiao Tao Xiao |
| author_sort | Zi-Yue Zhao |
| collection | DOAJ |
| description | Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice. |
| first_indexed | 2024-12-12T00:02:24Z |
| format | Article |
| id | doaj.art-13bd9bd61106486eb3b44c2f924e2766 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T00:02:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-13bd9bd61106486eb3b44c2f924e27662022-12-22T00:45:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.916915916915Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapyZi-Yue Zhao0Zi-Yue Zhao1Zhuo-Yuan Chen2Zhuo-Yuan Chen3Bin Yu4Bin Yu5Bo Xiao6Bo Xiao7Li-Yan Liu8Li-Yan Liu9Yu Xia10Yu Xia11Ao-Yu Li12Ao-Yu Li13Ping-Xiao Wang14Ping-Xiao Wang15Cheng Xiang16Cheng Xiang17Chao Liu18Chao Liu19Hui-Qin Yang20Hui-Qin Yang21Hui-Qin Yang22Hui Li23Hui Li24Tao Xiao25Tao Xiao26Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, The Affiliated yanan Hospital of Kunming Medical University, Kunming, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaDepartment of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, ChinaOrthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, ChinaMyxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2022.916915/fullMFSICITMEprognosisimmunotherapy |
| spellingShingle | Zi-Yue Zhao Zi-Yue Zhao Zhuo-Yuan Chen Zhuo-Yuan Chen Bin Yu Bin Yu Bo Xiao Bo Xiao Li-Yan Liu Li-Yan Liu Yu Xia Yu Xia Ao-Yu Li Ao-Yu Li Ping-Xiao Wang Ping-Xiao Wang Cheng Xiang Cheng Xiang Chao Liu Chao Liu Hui-Qin Yang Hui-Qin Yang Hui-Qin Yang Hui Li Hui Li Tao Xiao Tao Xiao Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy Frontiers in Immunology MFS ICI TME prognosis immunotherapy |
| title | Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| title_full | Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| title_fullStr | Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| title_full_unstemmed | Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| title_short | Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| title_sort | characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy |
| topic | MFS ICI TME prognosis immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916915/full |
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